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Titolo:
LITHIUM-THERAPY IN THE TREATMENT OF MANIC-DEPRESSIVE ILLNESS - PRESENT STATUS AND FUTURE PERSPECTIVES - A CRITICAL-REVIEW
Autore:
EMILIEN G; MALOTEAUX JM; SEGHERS A; CHARLES G;
Indirizzi:
WYETH AYERST RES,EUROPEAN CR&D DEPT,80 AVE PRESIDENT WILSON F-92031 PARIS FRANCE BRISTOL MYERS SQUIBB,PHARMACEUT RES INST B-1410 WATERLOO BELGIUM UNIV CATHOLIQUE LOUVAIN,CLIN UNIV ST LUC,PHARMACOL LAB B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,CLIN UNIV ST LUC,DEPT PSYCHIAT B-1200 BRUSSELS BELGIUM
Titolo Testata:
Archives internationales de pharmacodynamie et de therapie
fascicolo: 3, volume: 330, anno: 1995,
pagine: 251 - 278
SICI:
0003-9780(1995)330:3<251:LITTOM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLABORATIVE STUDY-GROUP; CYCLING BIPOLAR DISORDER; SERUM LITHIUM; TREATED RATS; BOVINE BRAIN; PHOSPHOINOSITIDE METABOLISM; CARBAMAZEPINE THERAPY; SODIUM VALPROATE; CEREBRAL-CORTEX; PHARMACOKINETICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
G. Emilien et al., "LITHIUM-THERAPY IN THE TREATMENT OF MANIC-DEPRESSIVE ILLNESS - PRESENT STATUS AND FUTURE PERSPECTIVES - A CRITICAL-REVIEW", Archives internationales de pharmacodynamie et de therapie, 330(3), 1995, pp. 251-278

Abstract

This article reviews critically the present status of lithium in the treatment and prophylaxis of manic-depressive illness compared to the two anticonvulsant drugs, carbamazepine and valproic acid, Lithium is used successfully in the prophylaxis and treatment of manic-depression. The mechanism by which it exerts its effects is still not very clear. There is much evidence to indicate that lithium may exert its therapeutic action by interfering with the metabolism of phosphoinositides which play an important role in synaptic transmission. Because of lithium's narrow therapeutic/toxic ratio, blood concentration monitoring iscrucial. Published data suggest that, compared to lithium, carbamazepine is similar in its relative specificity in treating mania, It is often faster in achieving its antimanic effects and best established as an alternative for patients not responding or intolerant to lithium, Carbamazepine is a good substitute for lithium when severe renal problems exclude the use of lithium. The therapeutic profile of valproic acid in manic-depression, although less extensively studied, appears to be similar to that of carbamazepine. As carbamazepine, it seems to be best indicated in patients with rapid cycles. Whereas lithium inhibits myo-inositol monophosphatase, carbamazepine shows a stimulating effectand valproic acid has no effect on this biochemical target. The implication of the inositol pathway in the pathogenesis of adverse effects,such as neurotoxicity and dermatological irritation, is discussed. A further understanding of this pathway is important for the future development of new lithium-like compounds in order to maximize the therapeutic benefits without the adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:35:25