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Titolo:
PET MEASUREMENTS OF NEURORECEPTOR OCCUPANCY BY TYPICAL AND ATYPICAL NEUROLEPTICS
Autore:
GOYER PF; BERRIDGE MS; MORRIS ED; SEMPLE WE; COMPTONTOTH BA; SCHULZ C; WONG DF; MIRALDI F; MELTZER HY;
Indirizzi:
VET AFFAIRS MED CTR B,10000 BRECKSVILLE RD BRECKSVILLE OH 44141 VET AFFAIRS MED CTR CLEVELAND OH 00000 CASE WESTERN RESERVE UNIV,SCH MED,DEPT RADIOL CLEVELAND OH 00000 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PSYCHIAT CLEVELAND OH 00000 UNIV HOSP CLEVELAND CLEVELAND OH 00000 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL BALTIMORE MD 21205
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 7, volume: 37, anno: 1996,
pagine: 1122 - 1127
SICI:
0161-5505(1996)37:7<1122:PMONOB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; DOPAMINE RECEPTOR OCCUPANCY; CLOZAPINE-TREATED PATIENTS; F-18 N-METHYLSPIROPERIDOL; SEROTONIN RECEPTORS; SCHIZOPHRENIC-PATIENTS; CEREBRAL-CORTEX; BINDING; DENSITY;
Keywords:
PET; CARBON-11-N-METHYLSPIPERONE; NEURORECEPTOR OCCUPANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Goyer et al., "PET MEASUREMENTS OF NEURORECEPTOR OCCUPANCY BY TYPICAL AND ATYPICAL NEUROLEPTICS", The Journal of nuclear medicine, 37(7), 1996, pp. 1122-1127

Abstract

The goal of this study was to use PET and C-11-N-methylspiperone (C-11-NMSP) to measure the differences in relative occupancy of serotonin (5-hydroxytryptamine-2 or 5-HT24) and dopamine-2 (D2) neuroreceptors in subjects being treated with typical or atypical antipsychotic drugs. Methods: We used PET and single-dose C-11-NMSP to measure receptor indices and relative receptor occupancy of 5-HT2A receptors in frontal cortex and D2 receptors in basal ganglia in five subjects who were neuroleptic free, five subjects who were being treated with typical antipsychotic drugs and five subjects who were being treated with clozapine,an atypical antipsychotic drug. Results: Among the three groups, there were significant differences in 5-HT2A indices, D2 indices and the ratio of 5-HT2A to D2 indices. With no overlap, the 5-HT2A index separated all subjects who received clozapine and the D2 index separated theremaining two groups. Conclusion: Typical antipsychotic and atypical antipsychotic subjects do have differing patterns of 5-HT2A and D2 relative-receptor occupancy when measured with a single PET scan, single C-11-NMSP radiotracer dose and no separately injected ''cold'' pharmaceutical.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:55:28