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Titolo:
MOLECULAR-CLONING OF BOVINE MB-1 CDNA
Autore:
YOUN HY; GOITSUKA R; KATO H; MASON DY; WATARI T; TSUJIMOTO H; HASEGAWA A;
Indirizzi:
UNIV TOKYO,FAC AGR,DEPT VET INTERNAL MED,BUNKYO KU,1-1-1 YOYOI TOKYO 113 JAPAN JOHN RADCLIFFE HOSP,DEPT HAEMATOL OXFORD OX3 9DU ENGLAND
Titolo Testata:
Veterinary immunology and immunopathology
fascicolo: 3, volume: 52, anno: 1996,
pagine: 191 - 200
SICI:
0165-2427(1996)52:3<191:MOBMC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; LEUKEMIA-VIRUS; NUCLEOTIDE-SEQUENCE; IG-BETA; B-CELLS; EXPRESSION; GENE; COMPLEX; ASSOCIATION;
Keywords:
BOVINE; B-LYMPHOCYTE; MB-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H.Y. Youn et al., "MOLECULAR-CLONING OF BOVINE MB-1 CDNA", Veterinary immunology and immunopathology, 52(3), 1996, pp. 191-200

Abstract

Ig-alpha of the B-cell antigen receptor complex forms a heterodimericstructure with Ig-beta on the plasma membrane of B-lymphocytes and isapparently involved in signal transduction during the activation of B-cells. Bovine leukemia virus (BLV) is predominantly a B-cell tropic retrovirus, which induces persistent lymphocytosis and leukemia/lymphoma of B-cell lineage in cattle. To understand the mechanisms of proliferation and tumorigenesis of bovine B-cells that are associated with BLV infection, we investigated the B-cell antigen receptor complex, especially bovine mb-1 encoding the bovine Ig-alpha protein. We isolated afull-length bovine mb-1 cDNA clone encoding 223 amino acid residues. The deduced amino acid sequence of the bovine mb-1 showed extensive homology with those of human and murine mb-1. The cytoplasmic tail of the bovine mb-1 also contained a consensus motif (D/E-X7-D/E-X2-L/I-X7-Y-X2-L/I) that may interact with the SH2 domain of src-type kinase. Interestingly, a similar consensus sequence motif was found in the BLV gp30(enu), although the overall sequence similarity between bovine mb-1 and BLVgp30 was not significant Furthermore, elevated levels of mb-1 transcript were detected in various bovine leukemia/lymphoma cell lines. These results indicated that the proliferation of B-cells associatedwith BLV-infection may be related to abnormal signal transduction through the B-cell antigen receptor complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:06:13