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Titolo:
MUTATIONS IN MASQUERADE, A NOVEL SERINE-PROTEASE-LIKE MOLECULE, AFFECT AXONAL GUIDANCE AND TASTE BEHAVIOR IN DROSOPHILA
Autore:
MURUGASUOEI B; BALAKRISHNAN R; YANG XH; CHIA W; RODRIGUES V;
Indirizzi:
NATL UNIV SINGAPORE,DEPT MOLEC & CELL BIOL,KENT RIDGE CRESCENT SINGAPORE 0511 SINGAPORE NATL UNIV SINGAPORE,DEPT MOLEC & CELL BIOL SINGAPORE 0511 SINGAPORE TATA INST FUNDAMENTAL RES,MOLEC BIOL UNIT BOMBAY 400005 MAHARASHTRA INDIA
Titolo Testata:
Mechanisms of development
fascicolo: 1, volume: 57, anno: 1996,
pagine: 91 - 101
SICI:
0925-4773(1996)57:1<91:MIMANS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURITE-PROMOTING FACTOR; GROWTH CONE GUIDANCE; GENETIC-ANALYSIS; NERVOUS-SYSTEM; INHIBITORY ACTIVITY; MELANOGASTER; ELEMENTS; ADULT; LOCALIZATION; EXPRESSION;
Keywords:
DROSOPHILA; MASQUERADE; AXONAL GUIDANCE; GUSTATORY PATHWAYS; NERVOUS SYSTEM DEVELOPMENT; SERINE-PROTEASE-LIKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
B. Murugasuoei et al., "MUTATIONS IN MASQUERADE, A NOVEL SERINE-PROTEASE-LIKE MOLECULE, AFFECT AXONAL GUIDANCE AND TASTE BEHAVIOR IN DROSOPHILA", Mechanisms of development, 57(1), 1996, pp. 91-101

Abstract

The masquerade (mas) locus encodes an extracellular molecule with a striking similarity to serine proteases. The serine residue, which is essential for enzymatic activity, has been substituted by glycine, suggesting that MAS could serve to antagonize serine protease activity [Murugasu-Oei et al. (1995), Genes Dev. 9, 139-154]. We describe the expression pattern of mas mRNA and protein in the developing embryonic, larval and pupal nervous system and in the epidermis. Total loss of mas function is lethal and results in aberrations in the embryonic centraland peripheral nervous systems, consistent with a role in axonal guidance. The possibility that the observed deficits in taste behavior, exhibited by animals with partial loss of mas function, are a result of defects in the adult brain are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:57:52