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Titolo:
PRESENCE AND EXPRESSION OF THE PX-GENE OF THE HUMAN-T-LYMPHOTROPIC-VIRUS TYPE-1 (HTLV-1) IN PATIENTS WITH GOUJEROT-SJOGRENS-SYNDROME
Autore:
LELIEVRE JD; CHEROT P; AGBALIKA F; MARIETTE X;
Indirizzi:
HOP ST LOUIS,MICROBIOL LAB,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE
Titolo Testata:
Medecine et maladies infectieuses
, volume: 26, anno: 1996, supplemento:, S
pagine: 875 - 878
SICI:
0399-077X(1996)26:<875:PAEOTP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
FRE
Soggetto:
CELL LEUKEMIA-VIRUS; AMPLIFICATION; SEQUENCES; DNA;
Keywords:
SJOGRENS SYNDROME; HTLV-1; PX; TAX; P21REX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Lelievre et al., "PRESENCE AND EXPRESSION OF THE PX-GENE OF THE HUMAN-T-LYMPHOTROPIC-VIRUS TYPE-1 (HTLV-1) IN PATIENTS WITH GOUJEROT-SJOGRENS-SYNDROME", Medecine et maladies infectieuses, 26, 1996, pp. 875-878

Abstract

The presence of the pX gene of the Human T Lymphotropic Virus Type 1 (HTVL-1) in the labial salivary glands of patients with Sjogren's syndrome (SS) has been documented, but a possible expression of this gene has not been assessed. We performed PCR on labial salivary glands of 40 patients with SS and found pX in 25% (10/40) of them. The other genes of HTVL-1 were not detected. Then we looked for the expression of this gene among those patients, We used recombinant proteins expressed in Escherichia coli to detect antibodies to Tax and p21Rex, proteins known to be encoded by the pX gene. No such antibodies were found in serum SS samples. ELISA and Western Blot analysis for structural proteinswere also negative. If those results seem to confirm a possible link beetween pX HTLV-1 and Sjogren's syndrome, they leave several questions unanswered, especially concerning the origin of the pX gene, presentin the LSG of SS patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:39:33