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Titolo:
DECREASED SUBSTANCE-P LEVELS IN RECTAL BIOPSIES FROM PATIENTS WITH SLOW TRANSIT CONSTIPATION
Autore:
TZAVELLA K; RIEPL RL; KLAUSER AG; VODERHOLZER WA; SCHINDLBECK NE; MULLERLISSNER SA;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,DEPT GASTROENTEROL,ROOM 230,ZIEMSSENSTR 1 D-80336 MUNICH GERMANY
Titolo Testata:
European journal of gastroenterology & hepatology
fascicolo: 12, volume: 8, anno: 1996,
pagine: 1207 - 1211
SICI:
0954-691X(1996)8:12<1207:DSLIRB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; IDIOPATHIC CHRONIC CONSTIPATION; SIGMOID COLON; GASTROINTESTINAL-TRACT; REGULATORY PEPTIDES; PERISTALTIC REFLEX; NERVE-FIBERS; HUMAN GUT; BISACODYL; NEUROTRANSMITTERS;
Keywords:
CONSTIPATION; SLOW TRANSIT; NEUROPEPTIDES; VASOACTIVE INTESTINAL POLYPEPTIDE; SOMATOSTATIN; SUBSTANCE P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
K. Tzavella et al., "DECREASED SUBSTANCE-P LEVELS IN RECTAL BIOPSIES FROM PATIENTS WITH SLOW TRANSIT CONSTIPATION", European journal of gastroenterology & hepatology, 8(12), 1996, pp. 1207-1211

Abstract

Objective: Previous studies in patients with chronic constipation found abnormalities in the nervous tissue of the large intestine, predominantly in the muscularis externa. Since there is evidence that the nervous system of mucosa and submucosa is also involved in the control ofcolonic motility we investigated the contents of vasoactive intestinal polypeptide (VIP), somatostatin and substance P in rectal biopsies of patients with slow colonic transit constipation. Design and methods:Twenty-two patients (17 females, 5 males) with chronic slow transit constipation toro-anal transit with radio-opaque markers on high fibre diet > 70 h) and long-term use of laxatives, and 20 controls (12 females, 8 males) with no history of constipation, were included in this study. Large rectal biopsy specimens including the submucosa were obtained from 5 cm above the dentate line and frozen in liquid nitrogen. After microdissection of the biopsies into mucosa and submucosa the neuropeptides were extracted by boiling and homogenizing the tissue in acetic acid and determined using validated radioimmunoassays. Results: Patients with slow transit constipation showed, compared to healthy controls, significantly lower levels of the excitatory neurotransmitter substance P in the mucosa and submucosa of rectal biopsies. There was no difference between the two groups concerning the levels of the inhibitory neurotransmitters, VIP and somatostatin. Conclusion: Slow transit constipation is associated with abnormalities of the substance P content of the enteric nervous system of mucosa and submucosa. This seems not to be related to chronic laxative use, since anthranoids cause a reduction in the levels of inhibitory neurotransmitters (VIP, somatostatin), but not of substance P, in the rat colon.

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Documento generato il 29/11/20 alle ore 03:12:42