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Titolo:
DYSPEPSIA TREATMENT WITH AL COMPOUNDS WIDELY USED IN CLINICAL-PRACTICE - AN ANIMAL-MODEL APPROACH
Autore:
PINHEIRO T; CANENA J; REIS J; SANTOS AM; PINTO AS; QUINA MG; REIS MA; ALVES LC;
Indirizzi:
NUCL & TECHNOL INST,DEPT PHYS,EN 10 P-2685 SACAVEM PORTUGAL NEW UNIV LISBON,FAC MED SCI,CLIN INTERNAL MED & GASTROENTEROL P-1700 LISBON PORTUGAL
Titolo Testata:
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms
, volume: 109, anno: 1996,
pagine: 318 - 322
SICI:
0168-583X(1996)109:<318:DTWACW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALUMINUM ABSORPTION; PIXE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Pinheiro et al., "DYSPEPSIA TREATMENT WITH AL COMPOUNDS WIDELY USED IN CLINICAL-PRACTICE - AN ANIMAL-MODEL APPROACH", Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, 109, 1996, pp. 318-322

Abstract

The potential toxic effects of Al to organs and tissues used in drugscommonly applied in dyspepsia as therapeutic, have been studied. Brain, liver, kidney and serum samples obtained from Wistar rats treated with two commercial Al complexes were studied and compared with equivalent samples collected from healthy animals receiving a placebo. The major alterations found, connected with the persistent intake of medicaments based on Al compounds, are relative to the accumulation of Al in liver and kidney. Also, the Al levels increase in brain and serum of rats supplemented with one of the Al complexes used. In the liver and kidney samples analyzed alterations in the Cu and Zn content levels were observed. Furthermore, a tendency to the decrease of Fe content in kidney and an increase of the Mn levels in brain is observed. The elemental alterations found are probably related to the intake of the drugstested and are dependent on the type of the Al complex administered. The results obtained suggest that the long term use of these medicaments in the clinical practice should be thought over.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:25:07