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Titolo:
SEROLOGICAL RESPONSES TO HUMAN PAPILLOMAVIRUS TYPE-6 AND TYPE-16 VIRUS-LIKE PARTICLES IN PATIENTS WITH CERVICAL NEOPLASTIC LESIONS
Autore:
SASAGAWA T; INOUE M; LEHTINEN M; ZHANG W; GSCHMEISSNER SE; HAJIBAGHERI MAN; FINCH J; CRAWFORD L;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT OBSTET & GYNECOL,13-1 TAKARAMACHI KANAZAWAISHIKAWA 920 JAPAN UNIV CAMBRIDGE,IMPERIAL CANC RES FUND,TUMOUR VIRUS GRP,DEPT PATHOL CAMBRIDGE CB2 1QP ENGLAND IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND MRC,MOLEC BIOL LAB CAMBRIDGE CB2 2QH ENGLAND NATL PUBL HLTH INST HELSINKI FINLAND TAMPERE UNIV,TAMPERE SCH PUBL HLHT SF-33101 TAMPERE FINLAND
Titolo Testata:
Clinical and diagnostic laboratory immunology
fascicolo: 4, volume: 3, anno: 1996,
pagine: 403 - 410
SICI:
1071-412X(1996)3:4<403:SRTHPT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN READING FRAMES; LINEAR EPITOPES; L1 PROTEIN; ANTIBODIES; DNA; CANCER; CELLS; SERA; PREVALENCE; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
T. Sasagawa et al., "SEROLOGICAL RESPONSES TO HUMAN PAPILLOMAVIRUS TYPE-6 AND TYPE-16 VIRUS-LIKE PARTICLES IN PATIENTS WITH CERVICAL NEOPLASTIC LESIONS", Clinical and diagnostic laboratory immunology, 3(4), 1996, pp. 403-410

Abstract

Serum samples from 36 cervical carcinoma patients, 33 patients with high-grade squamous intraepithelial lesions, and 31 cytologically normal women were tested by enzyme-linked immunosorbent assay (ELISA) usinghuman papilloma virus type 6 (HPV 6) and HPV 16 virus-like particles as antigens. Forty serum specimens from 1-year-old children were used to assign cutoff points. When serum samples from the subjects infectedwith HPV 16 were tested in an HPV 16 ELISA detecting immunoglobulin A(IgA), IgG, and IgM binding, 61% showed IgA, 44% showed IgG, and 39% showed IgM reactivity. Of HPV 6- or 11- or HPV 18-infected subjects, fewer than 17% showed IgA or IgG responses and 33% showed IgM reactivity. In contrast, 13% showed IgA, 10% showed IgG, and 16% showed IgM reactivity in the HPV DNA-negative controls. The results suggest that theIgA and IgG responses are HPV 16 specific and the IgM response is cross-reactive to different HPV types. On the other hand, the serologicalresponses to HPV 6 did not differ in the patient and control groups. The percentages of patients positive for both IgA and IgG antibodies were significantly higher in the groups with high-grade squamous intraepithelial lesions (12% [4 of 33]; P = 0.04) and cancer (17% [6 of 36];P = 0.02) than in the healthy women (0% [0 of 31]), and the percentages for either IgA or IgG were higher for the cancer group (47% [17 of 36]; P = 0.01) than in the normal group (19% [6 of 31]). Most sera positive for IgA and IgG in the patient groups showed higher titers than those in the normal group. All these results suggest that high IgA andIgG responses are good indicators for estimating HPV 16 infection.

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Documento generato il 01/10/20 alle ore 07:39:27