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Titolo:
CHARACTERISTICS OF GLYCEMIA-SENSITIVE NEURONS IN THE NUCLEUS-TRACTUS-SOLITARII - POSSIBLE INVOLVEMENT IN NUTRITIONAL REGULATION
Autore:
YETTEFTI K; ORSINI JC; PERRIN J;
Indirizzi:
UNIV AIX MARSEILLE 1,UPR 9024 CNRS,NEUROBIOL LAB,31 CHEMIN JOSEPH AIGUIER F-13402 MARSEILLE 20 FRANCE UNIV AIX MARSEILLE 1,UPR 9024 CNRS,NEUROBIOL LAB F-13402 MARSEILLE 20FRANCE
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 61, anno: 1997,
pagine: 93 - 100
SICI:
0031-9384(1997)61:1<93:COGNIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL HYPOTHALAMIC NEURONS; BLOOD-GLUCOSE LEVEL; FREE-FEEDING RATS; INTESTINAL NUTRIENTS; SUPRAOPTIC NUCLEI; NOREPINEPHRINE; PROJECTIONS; BRAIN; REPRESENTATION; GLUCOPRIVATION;
Keywords:
SOLITARY TRACT NUCLEUS; UNIT ACTIVITY; MICROELECTROPHORESIS; CLONIDINE; GLUCOSE; HYPERGLYCEMIA; HYPOGLYCEMIA; CATECHOLAMINERGIC NEURONS; FEEDING BEHAVIOR; ENERGY BALANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
K. Yettefti et al., "CHARACTERISTICS OF GLYCEMIA-SENSITIVE NEURONS IN THE NUCLEUS-TRACTUS-SOLITARII - POSSIBLE INVOLVEMENT IN NUTRITIONAL REGULATION", Physiology & behavior, 61(1), 1997, pp. 93-100

Abstract

Single unit responses to moderate glycemic variations were extracellularly recorded in the caudal division of the nucleus tractus solitariiof rats anesthetized by IV infusion of ketamine. As previously observed, a majority of recorded neurons (70%) were either activated or depressed by moderate hyperglycemia. Responses were consistently reproducible and amplitude was dependent on the maximum level of hyperglycemia. All glycemia-sensitive neurons responded in opposite directions to induced hyperglycemia and hypoglycemia, and almost all displayed the same type of response to local and IV glucose administration. Most glycemia-sensitive neurons were depressed by iontophoresis of clonidine, suggesting that they were adrenergic or noradrenergic. Based on these findings, we speculate that glycemia-sensitive neurons in the caudal nucleus tractus solitarii may act as glucose sensors that transmit glycemic information corresponding to different nutritional states, as well as other relevant signals toward hypothalamic structures involved in feeding and metabolic regulation via ascending adrenergic and noradrenergic pathways. Copyright (C) 1996 Elsevier Science Inc.

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Documento generato il 02/04/20 alle ore 18:49:54