Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MERCURY DISTRIBUTION AND RENAL METALLOTHIONEIN INDUCTION AFTER SUBCHRONIC ORAL-EXPOSURE IN RATS
Autore:
MORCILLO MA; SANTAMARIA J;
Indirizzi:
CIEMAT,DIV ISOTOPOS,AVD COMPLUTENSE 22 E-28040 MADRID SPAIN
Titolo Testata:
BioMetals
fascicolo: 3, volume: 9, anno: 1996,
pagine: 213 - 220
SICI:
0966-0844(1996)9:3<213:MDARMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL NEPHRECTOMY; INORGANIC MERCURY; CADMIUM-METALLOTHIONEIN; CHLORIDE; BINDING; KIDNEY; ZINC; LIVER; ACCUMULATION; PROTEINS;
Keywords:
MERCURY; KIDNEY; METALLOTHIONEIN; ORAL EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Morcillo e J. Santamaria, "MERCURY DISTRIBUTION AND RENAL METALLOTHIONEIN INDUCTION AFTER SUBCHRONIC ORAL-EXPOSURE IN RATS", BioMetals, 9(3), 1996, pp. 213-220

Abstract

The effects of long-term daily intake of low and high levels of mercury on its organ distribution and binding to renal metallothionein (MT)in male rats were studied, The animals were exposed to mercuric chloride labelled with Hg-203 via drinking water for 8 weeks (5, 50 and 500mu M Hg). The greatest concentration of mercury was found in the kidneys, Similar levels of radioactivity in the buccal cavity and oesophagus were also observed by whole-body autoradiography, In the kidneys, the mercury was accumulated in the outer stripe of the outer zone of the medulla and, to a minor degree, in the renal cortex. Almost 50% the total renal mercury was associated to MT. The binding capacity of the renal MT for mercury tends to saturate with increasing doses, thus this means that the capacity of the kidneys to accumulate mercury is limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:20:02