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Titolo:
MYOCARDIAL BETA-ADRENOCEPTOR DENSITY AND PLASMA-CATECHOLAMINES IN SYNDROME-X
Autore:
ROSEN SD; BOYD H; RHODES CG; KASKI JC; CAMICI PG;
Indirizzi:
HAMMERSMITH HOSP,CTR CLIN SCI,MRC,DU CANE RD LONDON W12 0HS ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH LONDON W12 0HS ENGLAND ST GEORGE HOSP,SCH MED LONDON ENGLAND
Titolo Testata:
The American journal of cardiology
fascicolo: 1, volume: 78, anno: 1996,
pagine: 37 - 42
SICI:
0002-9149(1996)78:1<37:MBDAPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ADRENERGIC-RECEPTOR DENSITY; HEART-FAILURE; CHEST PAIN; CARDIOMYOPATHY; SENSITIVITY; CGP-12177; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Rosen et al., "MYOCARDIAL BETA-ADRENOCEPTOR DENSITY AND PLASMA-CATECHOLAMINES IN SYNDROME-X", The American journal of cardiology, 78(1), 1996, pp. 37-42

Abstract

Recent research has cast doubt on the ischemic hypothesis of etiologyof syndrome X (anginal pain, ischemic-like changes in the stress electrocardiogram, but normal coronary arteriogram). Abnormalities of painperception have been shown and abnormal sympathetic nervous system activation has also been implicated. The aim of this study was to test the hypothesis that downregulation of myocardial beta adrenoceptors is demonstrable in patients with syndrome X. Such downregulation would beconsistent with raised myocardial catecholamine concentrations. We performed positron emission tomography with C-11-CGP-12177 to measure beta-adrenoceptor density. Plasma catecholamines were sampled simultaneously and assayed using high-performance liquid chromatography. Twenty syndrome X patients (11 female, age 57 +/- 9 SD years, range 33 to 69)and 18 matched controls (9 women, age 50 +/- 13 years, range 25 to 65; p = NS vs patients) were studied. Myocardial beta-adrenoceptor density did not differ between syndrome X patients and controls: 8.0 (1.9) pmol/g for patients versus 8.3 (2.1) pmol/g for controls; p = 0.62. Nodifferences were found between patients and controls for plasma norepinephrine (2.82 [1.07] and 2.76 [1.18] nM, respectively; p = 0.89) or for epinephrine (0.29 [0.14] and 0.30 [0.20] nM, respectively; p = 0.84). In patients with syndrome X, beta-adrenoceptor density is normal and, by inference, myocardial catecholamines would also be normal. Thisweakens the case for a generalized enhancement of sympathetic activation in this disorder, although increased sympathetic reactivity duringactual episodes of chest pain remains a possibility.

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Documento generato il 26/09/20 alle ore 12:32:45