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Titolo:
INHIBITION OF GLUTAMINE-SYNTHETASE ACTIVITY PREVENTS MEMORY CONSOLIDATION
Autore:
GIBBS ME; ODOWD BS; HERTZ L; ROBINSON SR; SEDMAN GL; NG KT;
Indirizzi:
MONASH UNIV,DEPT PSYCHOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT PSYCHOL CLAYTON VIC 3168 AUSTRALIA UNIV SASKATCHEWAN,COLL MED,DEPT PHARMACOL SASKATOON SK 87N 0W0 CANADA UNIV QUEENSLAND,DEPT PHYSIOL & PHARMACOL ST LUCIA QLD 4072 AUSTRALIA LA TROBE UNIV,SCH PSYCHOL BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Cognitive brain research
fascicolo: 1, volume: 4, anno: 1996,
pagine: 57 - 64
SICI:
0926-6410(1996)4:1<57:IOGAPM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY CULTURES; PYRUVATE-CARBOXYLASE; MAMMALIAN BRAIN; AMINO-ACIDS; CHICK BRAIN; RAT-BRAIN; METABOLISM; ASTROCYTES; NEUROTRANSMITTER; LOCALIZATION;
Keywords:
MEMORY CONSOLIDATION; PASSIVE AVOIDANCE TRAINING; DAY-OLD CHICK; METHIONINE SULFOXIMINE; GLUTAMINE SYNTHETASE; GLUTAMATE-GLUTAMINE CYCLE; GLUTAMATE; GLUTAMINE; ALPHA-KETOGLUTARATE; ALANINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Gibbs et al., "INHIBITION OF GLUTAMINE-SYNTHETASE ACTIVITY PREVENTS MEMORY CONSOLIDATION", Cognitive brain research, 4(1), 1996, pp. 57-64

Abstract

Methionine sulfoximine, a specific inhibitor of the exclusively glialenzyme glutamine synthetase, was shown, at a concentration of 3.5-4.5mM, to prevent consolidation of memory for a passive avoidance task in day-old chicks. Provided the drug was administered 5-20 min before the learning task, significant retention loss was observed from the normal time of onset of the second of three postulated stages in the memory formation sequence but the drug had to be administered considerablyearlier. The amnestic effect of methionine sulfoximine was successfully counteracted by L-glutamine (10 mM) and monosodium glutamate (4 mM), and also by a cocktail of alpha-ketoglutarate (5 mM) and alanine (5 mM). This effect of methionine sulfoximine is attributed to its blockade of the production of glutamine via the glutamate-glutamine cycle, leading to a reduced capacity of neurons to replenish their transmitterglutamate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:16:05