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Titolo:
INDIVIDUAL AND COMBINED EFFECTS OF ETHANOL AND COCAINE ON INTRACELLULAR SIGNALS AND GENE-EXPRESSION
Autore:
TORRES G; HOROWITZ JM;
Indirizzi:
SUNY BUFFALO,DEPT PSYCHOL,BEHAV NEUROSCI PROGRAM BUFFALO NY 14260
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 4, volume: 20, anno: 1996,
pagine: 561 - 596
SICI:
0278-5846(1996)20:4<561:IACEOE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; STRIATAL C-FOS; NUCLEOTIDE-BINDING-PROTEINS; VENTRAL TEGMENTAL AREA; DOPAMINE-RECEPTOR GENE; PITUITARY-ADRENAL AXIS; CENTRAL-NERVOUS-SYSTEM; KAPPA-OPIOID RECEPTOR; FREELY MOVING RATS; BEHAVIORAL SENSITIZATION;
Keywords:
ADDICTION; COCAETHYLENE; DOPAMINE; GENE EXPRESSION; GLUTAMATE; HUMAN; INTRACELLULAR MESSENGERS; NEUROPEPTIDES; PHOSPHOPROTEINS; RAT; STRIATUM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
198
Recensione:
Indirizzi per estratti:
Citazione:
G. Torres e J.M. Horowitz, "INDIVIDUAL AND COMBINED EFFECTS OF ETHANOL AND COCAINE ON INTRACELLULAR SIGNALS AND GENE-EXPRESSION", Progress in neuro-psychopharmacology & biological psychiatry, 20(4), 1996, pp. 561-596

Abstract

1. Ethanol and cocaine are drugs of abuse that can produce long-livedchanges in including dependence. 2. A common set of neural pathways appears to mediate the addictive actions of and cocaine. 3. Many prominent aspects of drug dependence may be the result of alterations in intracellular signals as well as specific patterns of gene expression. 4. For instance, changes in G proteins and cAMP, phosphorylation of proteins and induction of c-fos and zif/268 in specific drug-sensitive brain regions may represent adaptive changes in response to a drug-dependent state. 5. The concurrent use of ethanol and cocaine is the most prevalent pattern of drug abuse in humans. However, the number of studies investigating the behavioral and molecular effects of this combination are few. 6. Emerging evidence indicates a possible antagonistic effect of ethanol and cocaine action on transcription factor function. Inaddition, cocaethylene (a psychoactive metabolite derived from combined ethanol and cocaine exposure) has significant effects on gene expression as well.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 03:23:11