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Titolo:
IMMUNOPATHOGENESIS OF RECURRENT VULVO-VAGINAL CANDIDIASIS
Autore:
FIDEL PL; SOBEL JD;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT MICROBIOL IMMUNOL & PARASITOL,1901 PERDIDO ST NEW ORLEANS LA 70112 WAYNE STATE UNIV,SCH MED,DIV INFECT DIS DETROIT MI 48201
Titolo Testata:
Clinical microbiology reviews
fascicolo: 3, volume: 9, anno: 1996,
pagine: 335 -
SICI:
0893-8512(1996)9:3<335:IORVC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MUCOCUTANEOUS CANDIDIASIS; EXPERIMENTAL VAGINAL CANDIDIASIS; INDUCED LYMPHOCYTE-PROLIFERATION; SECRETED ASPARTATE PROTEINASE; FEMALE REPRODUCTIVE-TRACT; CELL-MEDIATED-IMMUNITY; GERM TUBE FORMATION; CANDIDAL VAGINITIS; T-CELLS; GNOTOBIOTIC MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
117
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Fidel e J.D. Sobel, "IMMUNOPATHOGENESIS OF RECURRENT VULVO-VAGINAL CANDIDIASIS", Clinical microbiology reviews, 9(3), 1996, pp. 335

Abstract

Recurrent vulvovaginal candidiasis (RVVC) is a prevalent opportunistic mucosal infection, caused predominantly by Candida albicans, which affects a significant number of otherwise healthy women of childbearingage. Since there are no known exogenous predisposing factors to explain the incidence of symptomatic vaginitis in most women with idiopathic RVVC, it has been postulated that these particular women suffer froman immunological abnormality that predisposes them to RVVC. Because of the increased incidence of mucosal candidiasis in individuals with depressed cell-mediated immunity (CMI), defects in CMI are viewed as a possible explanation for RVVC. In this review, we attempt to place into perspective the accumulated information regarding the immunopathogenesis of RVVC, as well as to provide new immunological perspectives andhypotheses regarding potential immunological deficiencies that may predispose to RVVC and potentially other mucosal infections by the same organism. The results of both clinical studies and studies in an animal model of experimental vaginitis suggest that systemic CMI may not bethe predominant host defense mechanism against C. albicans vaginal infections. Rather, locally acquired mucosal immunity, distinct from that in the peripheral circulation, is now under consideration as an important host defense at the vaginal mucosa, as well as the notion that changes in local CMI mechanism(s) may predispose to RVVC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:54:38