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Titolo:
DETECTION OF A VACUOLATING CYTOTOXIN IN STOOLS FROM CHILDREN WITH DIARRHEA
Autore:
LUZZI I; COVACCI A; CENSINI S; PEZZELLA C; CROTTI D; FACCHINI M; GIAMMANCO A; GUGLIELMETTI P; PIERSIMONI C; BONAMICO M; MARIANI P; RAPPUOLI R; CAPRIOLI A;
Indirizzi:
IST SUPER SANITA,BATTERIOL & MICOL MED LAB,VIALE REGINA ELENA 299 I-00161 ROME ITALY IST SUPER SANITA,ULTRASTRUTTURE LAB I-00161 ROME ITALY UNIV SIENA,IMMUNOBIOL RES INST SIENA I-53100 SIENA ITALY UNIV SIENA,INST MALATTIE INFETT I-53100 SIENA ITALY OSPED R SILVESTRINI PERUGIA ITALY OSPED BAMBINI V BUZZI MILAN ITALY UNIV PALERMO,DIPARTIMENTO IGIENE & MICROBIOL PALERMO ITALY UNIV ROMA LA SAPIENZA,CLIN PEDIAT 1 ROME ITALY OSPED NUOVO TORRETTE ANCONA ITALY
Titolo Testata:
Clinical infectious diseases
fascicolo: 1, volume: 23, anno: 1996,
pagine: 101 - 106
SICI:
1058-4838(1996)23:1<101:DOAVCI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOLYTIC-UREMIC SYNDROME; HELICOBACTER-PYLORI; ESCHERICHIA-COLI; PSEUDOMEMBRANOUS COLITIS; HUMAN FECES; TOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
I. Luzzi et al., "DETECTION OF A VACUOLATING CYTOTOXIN IN STOOLS FROM CHILDREN WITH DIARRHEA", Clinical infectious diseases, 23(1), 1996, pp. 101-106

Abstract

A cytotoxin inducing vacuolation in HEp-2 cells was detected in 19 (3.1%) of 618 stool specimens from children with diarrhea but in none of135 from control children, Common enteric pathogens were found in only two (10.5%) of the 19 cytotoxin-positive stool specimens, The vacuoles induced by stool filtrates resembled those induced by the vacuolating toxin (VacA) of Helicobacter pylori, The vacuolating toxin was heat-labile and protease-sensitive, and it had an apparent molecular weight of >100,000 but was not neutralized by an antiserum to H. pylori VacA, Although proper prospective case-control studies are needed to definitely assess the etiologic association between the new vacuolating cytotoxin and diarrhea, the present study suggests that microrganisms ofthe gastrointestinal tract produce a Helicobacter-like vacuolating toxin and may be responsible for cases of childhood diarrhea whose etiology is currently considered unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:41:48