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Titolo:
REGULATION OF MYOSIN PHOSPHATASE BY RHO AND RHO-ASSOCIATED KINASE (RHO-KINASE)
Autore:
KIMURA K; ITO M; AMANO M; CHIHARA K; FUKATA Y; NAKAFUKU M; YAMAMORI B; FENG JH; NAKANO T; OKAWA K; IWAMATSU A; KAIBUCHI K;
Indirizzi:
NARA INST SCI & TECHNOL,DIV SIGNAL TRANSDUCT IKOMA 63001 JAPAN NARA INST SCI & TECHNOL,DIV SIGNAL TRANSDUCT IKOMA 63001 JAPAN MIE UNIV,SCH MED,DEPT INTERNAL MED 1 TSU MIE 514 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL YOKOHAMA KANAGAWA 236 JAPAN
Titolo Testata:
Science
fascicolo: 5272, volume: 273, anno: 1996,
pagine: 245 - 248
SICI:
0036-8075(1996)273:5272<245:ROMPBR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; PHOSPHORYLATION; SENSITIVITY; SYSTEM; CELLS; RAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K. Kimura et al., "REGULATION OF MYOSIN PHOSPHATASE BY RHO AND RHO-ASSOCIATED KINASE (RHO-KINASE)", Science, 273(5272), 1996, pp. 245-248

Abstract

The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP . RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP . RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 15:58:27