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Titolo:
PRECLINICAL PHARMACOLOGY OF PRAMLINTIDE IN THE RAT - COMPARISONS WITHHUMAN AND RAT AMYLIN
Autore:
YOUNG AA; VINE W; GEDULIN BR; PITTNER R; JANES S; GAETA LSL; PERCY A; MOORE CX; KODA JE; RINK TJ; BEAUMONT K;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121
Titolo Testata:
Drug development research
fascicolo: 4, volume: 37, anno: 1996,
pagine: 231 - 248
SICI:
0272-4391(1996)37:4<231:PPOPIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLEUS MUSCLE; DIABETES-MELLITUS; PANCREATIC AMYLIN; SKELETAL-MUSCLE; NA+-K+; PEPTIDE; CALCITONIN; INSULIN; TRANSPORT; SECRETION;
Keywords:
GASTRIC EMPTYING; PHARMACOKINETICS; PHARMACODYNAMICS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Young et al., "PRECLINICAL PHARMACOLOGY OF PRAMLINTIDE IN THE RAT - COMPARISONS WITHHUMAN AND RAT AMYLIN", Drug development research, 37(4), 1996, pp. 231-248

Abstract

The pancreatic beta-cell hormone, amylin, is absent or reduced in individuals with type II diabetes mellitus and in many insulin-treated patients with type II diabetes. Amylin replacement therapy may be beneficial in these individuals, but the pharmaceutically inconvenient physicochemical properties of native human amylin led to the development instead of the amylin agonist, [Pro(25,28,29)]human amylin, or pramlintide (formerly designated AC137). Here we compare for rat amylin, human amylin and pramlintide, receptor binding and biological actions in rats in vivo and in rat soleus muscle. In the rat, the spectrum of actions and pharmacokinetic and pharmacodynamic properties of pramlintide are either very similar to, or indistinguishable from, those of rat or human amylin. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:06:24