Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COLOCALIZATION OF TYROSINE-HYDROXYLASE, NITRIC-OXIDE SYNTHASE AND NEUROPEPTIDES IN NEURONS OF THE HUMAN POSTNATAL MALE PELVIC GANGLIA
Autore:
JEN PYP; DIXON JS; GOSLING JA;
Indirizzi:
CHINESE UNIV HONG KONG,DEPT ANAT SHATIN HONG KONG CHINESE UNIV HONG KONG,DEPT ANAT SHATIN HONG KONG
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 59, anno: 1996,
pagine: 41 - 50
SICI:
0165-1838(1996)59:1-2<41:COTNSA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARACERVICAL GANGLIA; HUMAN-PROSTATE; NERVE-FIBERS; GUINEA-PIG; FEMALE RAT; SIF CELLS; LOCALIZATION; RELAXATION; BLADDER; NEUROCHEMISTRY;
Keywords:
PELVIC GANGLIA; NEUROPEPTIDES; NITRIC OXIDE SYNTHASE; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P.Y.P. Jen et al., "COLOCALIZATION OF TYROSINE-HYDROXYLASE, NITRIC-OXIDE SYNTHASE AND NEUROPEPTIDES IN NEURONS OF THE HUMAN POSTNATAL MALE PELVIC GANGLIA", Journal of the autonomic nervous system, 59(1-2), 1996, pp. 41-50

Abstract

Double-label immunocytochemistry was used to investigate the co-localisation of neuropeptides and the enzyme nitric oxide synthase (NOS) with tyrosine hydroxylase (TH) in autonomic ganglia of the human postnatal male pelvic plexus. Postmortem specimens were obtained from six male infants and children ranging in age from 2 to 12 months who had diedas a result of cot death or accidental trauma. On average, ganglia lying adjacent to the neck of the urinary bladder contained 45% of neurons which were TH-immunoreactive (-IR) while ganglia situated adjacent to the posterior and lateral aspects of the prostate gland contained 67% of neurons which were TH-IR. All the TH-IR neurons also contained dopamine beta-hydroxylase and were considered to be noradrenergic in type. On average, 61% of TH-IR neurons in bladder ganglia contained NOS,compared with 77% of non-TH-IR neurons (based on counts of over 1000 cells in each case), while the percentages of TH- and non-TH-IR neurons containing neuropeptides were: calcitonin gene-related peptide (CGRP) (30%; 11%), neuropeptide Y (NPY) (66%; 92%), somatostatin (SOM) (70%; 29%), substance P (SP) (64%; 46%), vasoactive intestinal polypeptide(VIP) (64%; 83%). The equivalent values for TH- and non-TH-IR neuronsin prostatic ganglia were NOS (38%; 59%), CGRP (55%; 18%), NPY (62%; 65%), SOM (14%; 20%), SP (13%; 8%) and VIP (42%; 82%). Varicose nerve fibers within the ganglia were seen forming pericellular arborizationsaround many of the ganglion cells, the most numerous containing TH-, CGRP-, NPY-, SOM- or VIP-immunoreactivity. Less common were pericellular varicosities containing SP-immunoreactivity while terminals containing NOS were not observed. No correlation could be detected between the peptide contents of the ganglion cells and of the associated pericellular terminals. However, the peptide content of the ganglion cells found in association with the urinary bladder and prostate gland correlates well with the previously documented coexistence of enzymes and neuropeptides in the intrinsic nerve fibers supplying these two regions of the human postnatal male genitourinary system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:51:38