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Titolo:
DEGRADATION OF BRADYKININ IN HUMAN URINE BY CARBOXYPEPTIDASE Y-LIKE EXOPEPTIDASE AND NEUTRAL ENDOPEPTIDASE AND THEIR INHIBITION BY EBELACTONE-B AND PHOSPHORAMIDON
Autore:
SAITO M; MAJIMA M; KATORI M; SANJOU Y; SUYAMA I; SHIOKAWA H; KOSHIBA K; AOYAGI T;
Indirizzi:
KITASATO UNIV,SCH MED,DEPT PHARMACOL,KITASATO 1-15-1 SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DEPT PHARMACOL SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DEPT UROL SAGAMIHARA KANAGAWA 228 JAPAN SHOWA COLL PHARMACEUT SCI,DEPT HYG MACHIDA TOKYO 194 JAPAN
Titolo Testata:
International journal on tissue reactions
fascicolo: 5-6, volume: 17, anno: 1995,
pagine: 181 - 190
SICI:
0250-0868(1995)17:5-6<181:DOBIHU>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-KIDNEY; RAT URINE; PURIFICATION; KALLIKREIN; KININASE; SALT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Saito et al., "DEGRADATION OF BRADYKININ IN HUMAN URINE BY CARBOXYPEPTIDASE Y-LIKE EXOPEPTIDASE AND NEUTRAL ENDOPEPTIDASE AND THEIR INHIBITION BY EBELACTONE-B AND PHOSPHORAMIDON", International journal on tissue reactions, 17(5-6), 1995, pp. 181-190

Abstract

incubation of bradykinin with human urine resulted in a successive degradation of bradykinin-(1-8), bradykinin-(1-7), bradykinin-(1-6), andbradykinin-(1-5). Although D,L-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (100 mu M) and captopril (100 mu M) did not have any significant effect on bradykinin degradation in human urine, the neutral endopeptidase inhibitor phosphoramidon (100 mu M), a carboxypeptidase Y-like exopeptidase inhibitor ebelactone B (100 mu M), and o-phenanthroline (100 mu M) significantly inhibited bradykinin degradation by 36%, 38% and 48% respectively. The combination of phosphoramidon and ebelactone B completely (by 95%) inhibited bradykinin degradation in humanurine. At pH 5, bradykinin degradation was performed by carboxypeptidase Y-like exopeptidase; at pH 7, this degradation was performed by neutral endopeptidase in addition to carboxypeptidase Y-like exopeptidase. From these results, it can be concluded that carboxypeptidase Y-like exopeptidase and/or neutral endopeptidase certainly have a role in kinin degradation in human urine under neutral and acid pH conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:21:20