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Titolo:
ROLE OF NPY NEURONS IN GH-DEPENDENT FEEDBACK SIGNALING TO THE BRAIN
Autore:
CHAN YY; CLIFTON DK; STEINER RA;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS,BOX 357290 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT OBSTET & GYNECOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MED SEATTLE WA 98195
Titolo Testata:
Hormone research
, volume: 45, anno: 1996, supplemento:, 1
pagine: 12 - 14
SICI:
0301-0163(1996)45:<12:RONNIG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION;
Keywords:
C-FOS; GROWTH HORMONE; GROWTH HORMONE RECEPTOR MESSENGER-RNA; GROWTH HORMONE-RELEASING HORMONE; NPY; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
Y.Y. Chan et al., "ROLE OF NPY NEURONS IN GH-DEPENDENT FEEDBACK SIGNALING TO THE BRAIN", Hormone research, 45, 1996, pp. 12-14

Abstract

The neuroendocrine regulation of pulsatile growth hormone (GH) secretion involves the reciprocal interactions between growth hormone-releasing hormone (GHRH)- and somatostatin-containing neurones, residing primarily in the hypothalamic arcuate nucleus (ARC) and the periventricular nucleus (PeN), respectively. Considerable evidence supports the concept that GH itself participates in the regulation of its own rhythmicsecretion through a reciprocal feedback on GHRH and somatostatin neurones. The direct actions of GH are mediated through GH receptors, and in the PeN, the majority of somatostatin neurones express this receptor. GH induces the expression of the immediate early gene c-fos in the ARC; however, few GHRH residing in the ARC express the GH receptor, suggesting that the action of GH on GHRH cells must be indirect through another population of unidentified cells. NPY neurones express c-fos in response to GH, and preliminary results suggest that NPY neurones inthe ARC express the GH receptor. These observations suggest that NPY neurones play a physiological role in the feedback of regulation of GHsecretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:22:56