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Titolo:
HIGH-PROTEIN DIETS ARE ASSOCIATED WITH INCREASED BACTERIAL TRANSLOCATION IN SEPTIC GUINEA-PIGS
Autore:
NELSON JL; ALEXANDER JW; GIANOTTI L; CHALK CL; PYLES T;
Indirizzi:
3229 BURNET AVE CINCINNATI OH 45229 UNIV CINCINNATI,MED CTR,SHRINERS BURNS INST CINCINNATI OH 45267 UNIV CINCINNATI,MED CTR,DEPT SURG CINCINNATI OH 45267
Titolo Testata:
Nutrition
fascicolo: 3, volume: 12, anno: 1996,
pagine: 195 - 199
SICI:
0899-9007(1996)12:3<195:HDAAWI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL PARENTERAL-NUTRITION; GLUTAMINE; SEPSIS; GUT; SURVIVAL; TRANSPORT; RATS;
Keywords:
BACTERIAL TRANSLOCATION; ENTERAL NUTRITION; SEPSIS; ESCHERICHIA COLI; INTESTINAL FUNCTION; PROTEIN; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Nelson et al., "HIGH-PROTEIN DIETS ARE ASSOCIATED WITH INCREASED BACTERIAL TRANSLOCATION IN SEPTIC GUINEA-PIGS", Nutrition, 12(3), 1996, pp. 195-199

Abstract

During sepsis, body protein stores are decreased due to an increase in protein catabolism. The utilization of nutritional support with high-protein diets has been used as a solution to the problem of sepsis-induced protein loss. Work from our laboratory, however, has shown that diets low in protein (5% of total calories) improve survival in septicanimals as compared to high protein (20%) diets. The present study investigated the relationship between low-protein diets and improved survival by determining whether septic animals receiving high protein diets have increased bacterial translocation. Sepsis was induced in guinea pigs by the implantation of an osmotic minipump into the peritoneal cavity containing an equal mixture of Escherichia coli (10(8)) and Staphylococcus aureus (10(8)) or saline. On Day 3 postlaparotomy, the animals were randomized to one of four groups. The groups consisted of septic and nonseptic animals that received a diet with 5 or 20% of totalcalories as protein. Following 4 days of diet all animals received aninstillation of C-14 labeled E. coli (10(10)). Four hours later the animals were sacrificed and blood, mesenteric lymph nodes, spleen, lungs, and liver were removed for determination of radionuclide counts. Results indicated that the septic animals that received the high proteindiet had more bacterial translocation, as indexed by higher radionuclide counts in the MLN, liver, lung and blood. These findings suggest that a low protein, enterally fed diet may improve survival in septic patients by decreasing the incidence of bacterial translocation.

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Documento generato il 14/07/20 alle ore 13:04:46