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Titolo:
RAGE - A NOVEL CELLULAR RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS
Autore:
SCHMIDT AM; HORI O; CAO R; YAN SD; BRETT J; WAUTIER JL; OGAWA S; KUWABARA K; MATSUMOTO M; STERN D;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,DEPT PHYSIOL,P&S 11-518,630 W 168TH STNEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT MED NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,DEPT SURG NEW YORK NY 10032 UNIV PARIS 07,FAC MED,HOP LARIBOISIERE,LAB RECH BIOL VASC & CELLULAIRE,UNITE IMMUNOHEMAT PARIS FRANCE OSAKA UNIV,SCH MED,DEPT MED 1 OSAKA 553 JAPAN
Titolo Testata:
Diabetes
, volume: 45, anno: 1996, supplemento:, 3
pagine: 77 - 80
SICI:
0012-1797(1996)45:<77:R-ANCR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE; COMPLICATIONS; PROTEINS; COLLAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Schmidt et al., "RAGE - A NOVEL CELLULAR RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS", Diabetes, 45, 1996, pp. 77-80

Abstract

Exposure of proteins to reducing sugars results in nonenzymatic glycation with the ultimate formation of advanced glycation end products (AGEs). One means through which AGEs modulate cellular functions is through binding to specific cell surface acceptor molecules. The receptor for AGEs (RAGE) is such a receptor and is a newly identified member ofthe immunoglobulin superfamily expressed on endothelial cells (ECs), mononuclear phagocytes (MPs), and vascular smooth muscle cells (SMCs) in both vivo and in vitro. Binding of AGEs to RAGE results in induction of cellular oxidant stress, as exemplified by the generation of thiobarbituric acid-reactive substances, expression of heme oxygenase typeI, and activation of the transcription factor NF-kB, with consequences for a range of cellular functions, AGEs on the surface of diabetic red cells enhance binding to endothelial RAGE and result in enhanced oxidant stress in the vessel wall. By using reagents to selectively block access to RAGE, the role of this receptor in AGE-mediated perturbation of cellular properties can be dissected in detail.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:26:19