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Titolo:
REGULATION OF THE B-CELL RESPONSE TO T-DEPENDENT ANTIGENS BY CLASSICAL PATHWAY COMPLEMENT
Autore:
FISCHER MB; MA MH; GOERG S; ZHOU XN; XIA JR; FINCO O; HAN SH; KELSOE G; HOWARD RG; ROTHSTEIN TL; KREMMER E; ROSEN FS; CARROLL MC;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT PATHOL,BLDG D-2,200 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PEDIAT BOSTON MA 02115 CTR BLOOD RES BOSTON MA 02115 BOSTON UNIV,SCH MED,DEPT MED BOSTON MA 02118 BOSTON UNIV,SCH MED,DEPT MICROBIOL BOSTON MA 02118 IRIS SIENA ITALY HEMATOLOGIKUM,INST IMMUNOL MUNICH GERMANY UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL BALTIMORE MD 21201
Titolo Testata:
The Journal of immunology
fascicolo: 2, volume: 157, anno: 1996,
pagine: 549 - 556
SICI:
0022-1767(1996)157:2<549:ROTBRT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE CDNA SEQUENCE; AMINO-ACID SEQUENCES; SEX-LIMITED PROTEIN; 4TH COMPONENT; LYMPHOCYTES-B; IMMUNE-RESPONSE; ANTIBODY-PRODUCTION; COMPLETE NUCLEOTIDE; MURINE COMPLEMENT; GERMINAL-CENTERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Fischer et al., "REGULATION OF THE B-CELL RESPONSE TO T-DEPENDENT ANTIGENS BY CLASSICAL PATHWAY COMPLEMENT", The Journal of immunology, 157(2), 1996, pp. 549-556

Abstract

Mice deficient in complement components C3 (C3-/-) and C4 (C4-/-) were found to have a profound defect in their Ab response to a T-dependent Ag (bacteriophage phi X174). Characterization of the deficient mice demonstrated a diminished level of peanut agglutinin(+) germinal centers and a failure in isotype switching despite normal B cell signaling in vitro. The nature of the defect was found to lie at the B cell level, as the T cells were primed in C3- and C4-deficient mice as well as those in wild-type mice. These results, and the finding that the defect could be partly reversed by a 10-fold increase in Ag dose, support the hypothesis that covalent attachment of complement ligands, i.e., C3b and C3d to the Ag-Ab complex, increases its immunogenicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:55:23