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Titolo:
IMMUNODETECTION OF APOPTOSIS-REGULATING PROTEINS IN LYMPHOMAS FROM PATIENTS WITH AND WITHOUT HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
Autore:
SCHLAIFER D; KRAJEWSKI S; GALOIN S; RIGALHUGUET F; LAURENT G; MASSIP P; PRIS J; DELSOL G; REED JC; BROUSSET P;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,PL DOCTEUR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,ANAT PATHOL LAB F-31059 TOULOUSE FRANCE CHU PURPAN,SERV HEMATOL,CLIN DIEULAFOY F-31059 TOULOUSE FRANCE CHU PURPAN,CIGH,CNRS F-31059 TOULOUSE FRANCE LA JOLLA CANC RES FDN LA JOLLA CA 92037 CHU RANGUEIL,SERV MALAD INFECT F-31054 TOULOUSE FRANCE
Titolo Testata:
The American journal of pathology
fascicolo: 1, volume: 149, anno: 1996,
pagine: 177 - 185
SICI:
0002-9440(1996)149:1<177:IOAPIL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; PROGRAMMED CELL-DEATH; EXPRESSION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D. Schlaifer et al., "IMMUNODETECTION OF APOPTOSIS-REGULATING PROTEINS IN LYMPHOMAS FROM PATIENTS WITH AND WITHOUT HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION", The American journal of pathology, 149(1), 1996, pp. 177-185

Abstract

The expression of the apoptosis-regulating genes Bcl-2, Bcl-x, Bax, Mcl-1, and p53 was analyzed in 4 cases of human immunodeficiency, virus(HIV)-associated Hodgkin's disease, in 36 cases of HIV-related non-Hodgkin's lymphomas (NHLs), and in 109 cases of non-HIV-related NHLs by using immunohistochemistry. HIV-associated Hodgkin's disease samples were positive for all markers. For the HIV-related NHL samples, 36, 66,88, 100, and 94% of the cases were Bcl-2, Bcl-x, Bax, Mcl-1, and p53 positive, respectively. For the HIV-unrelated NHLs, Bcl-2, Bcl-x, Bax,Mcl-1, and p53 were found to be expressed in 69, 65, 82, 83, and 42%,respectively. No significant differences were observed in Bax and Mcl-1 staining between HIV-related NHLs of B cell and T cell types. In contrast, Bcl-2 tons positive in 66/79 (83%) and 10/30 (33%) of B cell and T cell HIV-related NHLs, respectively (P2 < 0.001). Peculiar patterns were observed for hairy cell leukemia (Bax(+), Bcl-2(+), Mcl-1(-)) and for anaplastic large cell lymphoma (Bax(+), Mcl-1(+), Bcl-2(-)) inHIV-unrelated NHLs. Of interest, all cases with a positive expressionof Bax were also found to express either Mcl-1 and/or Bcl-2, suggesting that Mcl-1 and Bcl-2 may counteract the pro-apoptosis function of Bar in vivo by protein-protein interaction within the tumor cell, as demonstrated previously in vitro. These results suggest that apoptosis regulation may have a role in the pathogenesis of some HIV-related and HIV-unrelated NHLs.

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Documento generato il 04/12/20 alle ore 22:41:35