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Titolo:
COMMISSURAL NTS CONTRIBUTES TO PRESSOR-RESPONSES TO GLUTAMATE INJECTED INTO THE MEDIAL NTS OF AWAKE RATS
Autore:
COLOMBARI E; MENANI JV; TALMAN WT;
Indirizzi:
UNIV IOWA,DEPT NEUROL IOWA CITY IA 52242 UNIV IOWA,DEPT NEUROL IOWA CITY IA 52242 VET AFFAIRS MED CTR IOWA CITY IA 52242 PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 39, anno: 1996,
pagine: 1220 - 1225
SICI:
0363-6119(1996)39:6<1220:CNCTPT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; BRAIN-STEM; ARTERIAL-PRESSURE; CONSCIOUS RATS; PROJECTIONS;
Keywords:
ARTERIAL PRESSURE; BARORECEPTOR; CHEMORECEPTOR; EXCITATORY AMINO ACIDS; KCN; MEDULLA; NUCLEUS TRACTUS SOLITARII;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Colombari et al., "COMMISSURAL NTS CONTRIBUTES TO PRESSOR-RESPONSES TO GLUTAMATE INJECTED INTO THE MEDIAL NTS OF AWAKE RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 39(6), 1996, pp. 1220-1225

Abstract

In the present study we investigated whether interruption of the chemoreceptor reflex by an electrolytic lesion of the commissural subnucleus of the nucleus tractus solitarii (commNTS) influenced presser and bradycardic responses induced by microinjection of L-glutamate (L-Glu) into the medial NTS (mNTS) of conscious rats. Seven days after sham lesions, seven rats demonstrated significant presser [change in mean arterial pressure (MAP) = +33 +/- 3 mmHg] and bradycardic [change in heart rate (HR) = -74 +/- 8 beats/min (bpm)] responses to chemoreceptor reflex activation by intravenous injection of KCN. Likewise, L-Glu (1 nmol in 100 nl) injected into the mNTS in sham rats induced presser (+29+/- 2 mmHg) and bradycardic responses (-90 +/- 8 bpm). However, in 11rats with lesions in commNTS, presser and bradycardic chemoreceptor reflex responses were abolished, and injection of L-Glu into the mNTS decreased MAP (-14 +/- 6 mmHg) and HR (-59 +/- 16 bpm) as is reported in anesthetized control rats. We conclude that presser responses induced by L-Glu microinjected into the baroreceptor reflex region of mNTS in conscious rats depend on the integrity of the commNTS, which plays an important role in central chemoreceptor reflex pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:56:05