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Titolo:
MOBILIZATION OF PHILADELPHIA-NEGATIVE PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN CHRONIC MYELOID-LEUKEMIA USING HYDROXYUREA AND G-CSF (FILGRASTIM)
Autore:
JOHNSON RJ; OWEN RG; CHILD JA; MORGAN GJ; BARNARD DL; DICKINSON H; RICKETTS S; RAWSTRON A; EVANS P; WOODHEAD V; MAJOR K; ROBINSON F; SMITH GM;
Indirizzi:
GEN INFIRM,DEPT HAEMATOL,GREAT GEORGE ST LEEDS LS1 3EX W YORKSHIRE ENGLAND ST JAMES HOSP LEEDS LS9 7TF W YORKSHIRE ENGLAND
Titolo Testata:
British Journal of Haematology
fascicolo: 4, volume: 93, anno: 1996,
pagine: 863 - 868
SICI:
0007-1048(1996)93:4<863:MOPPM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE HYDROXYUREA; LEUKEMIA;
Keywords:
CHRONIC MYELOID LEUKEMIA; HYDROXYUREA; PERIPHERAL BLOOD STEM CELLS; PHILADELPHIA NEGATIVE; MOBILIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Johnson et al., "MOBILIZATION OF PHILADELPHIA-NEGATIVE PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN CHRONIC MYELOID-LEUKEMIA USING HYDROXYUREA AND G-CSF (FILGRASTIM)", British Journal of Haematology, 93(4), 1996, pp. 863-868

Abstract

A relatively simple and non-toxic out-patient-based regimen for the mobilization of Philadelphia-negative (Ph - ve) mononuclear cells in chronic myeloid leukaemia (CML) was evaluated in 10 patients, nine in stable chronic phase and one in accelerated phase. They received oral hydroxyurea at a mean dose of 3.5 g/m(2) daily for 7 d, followed by 300 mu g of G-CSF daily until the last day of harvesting. In the nine chronic-phase patients the mean number of days from the end of hydroxyureato the commencement of harvesting was 14.5 (range 10-18). The patientin accelerated phase recovered and was harvested after 6 d. The mean number of aphereses performed was 3.4. Adequate numbers of stem cells were obtained in 9/10 patients judged by our usual criteria. Side-effects were mild in comparison to published intravenous schedules. No patients lost their hair. Five (50%) patients required admission with neutropenic fever which responded to antibiotics in all cases. Four (40%)patients developed a transient rash and four (40%) experienced mild oral mucositis. This level of toxicity enabled half of the patients to be treated entirely on an out-patient basis. The harvest products wereanalysed for cells belonging to the leukaemic clone by conventional cytogenetics. FISH and PCR. All were PCR positive. The mean Ph positivities by cytogenetics and FISH were comparable at 18.1% and 15% respectively. Half the patients had > 98% normal metaphases. We conclude thatthis approach is comparable in efficacy to published intravenous regimens and significantly less toxic. It can be safely used at diagnosis before interferon therapy commences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:37:51