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Titolo:
INFLUENCE OF THE ASSESSMENT OF DEFECT SEVERITY AND INTRAVENOUS NITRATE ADMINISTRATION DURING TRACER INJECTION ON THE DETECTION OF VIABLE HIBERNATING MYOCARDIUM WITH DATA-BASED QUANTITATIVE TECHNETIUM 99M-LABELED SESTAMIBI SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY
Autore:
SCIAGRA R; BISI G; SANTORO GM; AGNOLUCCI M; ZOCCARATO O; FAZZINI PF;
Indirizzi:
UNIV FLORENCE,NUCL MED UNIT,DEPT CLIN PATHOPHYSIOL,VIALE MORGAGNI 85 I-50134 FLORENCE ITALY CAREGGI HOSP,DIV CARDIOL FLORENCE ITALY IRCCS,FDN CLIN LAVORO,MED CTR REHABIL VERUNO ITALY
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 3, volume: 3, anno: 1996,
pagine: 221 - 230
SICI:
1071-3581(1996)3:3<221:IOTAOD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; METHOXY ISOBUTYL ISONITRILE; LEFT-VENTRICULAR FUNCTION; DOBUTAMINE ECHOCARDIOGRAPHY; THALLIUM SCINTIGRAPHY; TL-201; REST; VIABILITY; IDENTIFICATION; REINJECTION;
Keywords:
MYOCARDIAL; VIABILITY; NITRATES; SESTAMIBI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Sciagra et al., "INFLUENCE OF THE ASSESSMENT OF DEFECT SEVERITY AND INTRAVENOUS NITRATE ADMINISTRATION DURING TRACER INJECTION ON THE DETECTION OF VIABLE HIBERNATING MYOCARDIUM WITH DATA-BASED QUANTITATIVE TECHNETIUM 99M-LABELED SESTAMIBI SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY", Journal of nuclear cardiology, 3(3), 1996, pp. 221-230

Abstract

Background. This study aimed to verify whether the assessment of defect severity and the infusion of nitrates during tracer injection improve the capability of data-based Tc-99m-labeled sestamibi single-photonemission computed tomography (SPECT) to recognize hibernating myocardium. Methods and Results. Of 66 asynergic coronary territories in 40 patients with left ventricular dysfunction, 28 had postrevascularization functional recovery (hibernating) and 38 had unchanged dysfunction (fibrotic), Defect severity was lower in the hibernating than in the fibrotic territories on both baseline (p < 0.01) and nitrate SPECT (p < 0.002), Nitrate was superior to baseline SPECT to differentiate the hibernating from the fibrotic territories (sensitivity 96% vs 75%, p < 0.05; receiver-operating characteristic curve area 0.75 vs 0.63, p < 0.001) and to identify the patients with improved left ventricular ejection fraction (receiver-operating characteristic curve area 0.68 vs 0.58; p < 0.05). Conclusions. The analysis of defect severity in combination with nitrate infusion clearly improves the value of Tc-99m-labeledsestamibi SPECT for the recognition of hibernating myocardium and theprediction of postrevascularization recovery.

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Documento generato il 25/11/20 alle ore 09:37:30