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Titolo:
TECHNETIUM 99M-LABELED TETROFOSMIN MYOCARDIAL TOMOGRAPHY IN PATIENTS WITH CORONARY-ARTERY DISEASE - COMPARISON BETWEEN ADENOSINE AND DYNAMIC EXERCISE STRESS-TESTING
Autore:
CUOCOLO A; NICOLAI E; SORICELLI A; PACE L; NAPPI A; SULLO P; CARDEI S; ARGENZIANO L; ELL PJ; SALVATORE M;
Indirizzi:
VIA POSILLIPO 66 I-80123 NAPLES ITALY UNIV NAPLES FEDERICO II,CATTEDRA MED NUCL,CNR,CTR MED NUCL NAPLES ITALY UNIV NAPLES FEDERICO II,CLIN MED 1 NAPLES ITALY UNIV COLL LONDON,INST NUCL MED LONDON ENGLAND
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 3, volume: 3, anno: 1996,
pagine: 194 - 203
SICI:
1071-3581(1996)3:3<194:T9TMTI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHOXY ISOBUTYL ISONITRILE; PERFUSION IMAGING AGENT; TL-201 SCINTIGRAPHY; TECHNETIUM-99M-TETROFOSMIN; DIPYRIDAMOLE;
Keywords:
MYOCARDIAL PERFUSION; ADENOSINE; TECHNETIUM 99M-LABELED TETROFOSMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Cuocolo et al., "TECHNETIUM 99M-LABELED TETROFOSMIN MYOCARDIAL TOMOGRAPHY IN PATIENTS WITH CORONARY-ARTERY DISEASE - COMPARISON BETWEEN ADENOSINE AND DYNAMIC EXERCISE STRESS-TESTING", Journal of nuclear cardiology, 3(3), 1996, pp. 194-203

Abstract

Background. Pharmacologic coronary vasodilation with adenosine, combined with myocardial scintigraphy, is a useful test for the diagnosis of coronary artery disease (CAD) in patients unable to exercise. It hasbeen demonstrated recently that exercise Tc-99m-labeled tetrofosmin cardiac imaging can be used for the detection of CAD. However, no data are available comparing Tc-99m-labeled tetrofosmin adenosine and exercise tests in the same patients. Methods and Results. The results of adenosine and exercise Tc-99m-labeled tetrofosmin myocardial tomography were compared in 41 patients (37 men and four women; mean age 53 +/- 8years) with suspected or known CAD who underwent coronary angiography, All patients were submitted, on separate days, to three injections of Tc-99m-labeled tetrofosmin (740 MBq intravenously): one at rest, oneduring bicycle exercise, and one during adenosine infusion (140 mu g/kg/min for 6 minutes with injection of Tc-99m-labeled tetrofosmin at 4minutes). A total of 902 myocardial segments were analyzed quantitatively. One patient had normal coronary vessels, 19 patients had single-vessel CAD, 12 patients had two-vessel CAD, and nine patients had three-vessel CAD (>50% coronary stenosis) on coronary angiography. Adenosine induced a significant increase in heart rate (88 +/- 16 beats/min at peak vs 72 +/- 11 beats/min at rest; p < 0.01). Systolic and diastolic blood pressure was not significantly different after adenosine infusion compared with rest, Double product was 22931 +/- 7039 at peak exercise and 11229 +/- 3413 after adenosine (p < 0.01). Agreement on the presence of abnormal single-photon emission computed tomography by adenosine and exercise was 100% by quantitative analysis, In all segmentsa significant relationship between exercise and adenosine Tc-99m-99m-labeled tetrofosmin uptake was observed (r = 0.90; p < 0.001). Segmental agreement for regional Tc-99m-labeled tetrofosmin uptake score between exercise and adenosine was observed in 737 (82%) of the 902 segments (kappa value of 0.66). Concordance between the two studies for identification of perfusion status was observed in 809 (90%) of the segments (kappa value of 0.80). Sensitivity and specificity for detection ofstenosed vessels were not different for dynamic exercise stress testing and adenosine Tc-99m-labeled tetrofosmin cardiac tomography. Conclusions. Despite different hemodynamic effects, adenosine and dynamic exercise Tc-99m-labeled tetrofosmin single-photon emission computed tomographic imaging provides similar information in the diagnosis and localization of CAD.

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Documento generato il 27/11/20 alle ore 22:30:15