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Titolo:
THE INVOLVEMENT OF CA2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN MEMORYFORMATION IN DAY-OLD CHICKS/
Autore:
ZHAO WQ; BENNETT P; RICKARD N; SEDMAN GL; GIBBS ME; NG KT;
Indirizzi:
MONASH UNIV,DEPT PSYCHOL CLAYTON VIC 3168 AUSTRALIA LA TROBE UNIV BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 1, volume: 66, anno: 1996,
pagine: 24 - 35
SICI:
1074-7427(1996)66:1<24:TIOCCP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; POSTSYNAPTIC DENSITY PROTEIN; SQUID GIANT SYNAPSE; II MUTANT MICE; NEUROTRANSMITTER RELEASE; RAT-BRAIN; CALMODULIN; CA-2+; MODEL; AUTOPHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
W.Q. Zhao et al., "THE INVOLVEMENT OF CA2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN MEMORYFORMATION IN DAY-OLD CHICKS/", Neurobiology of learning and memory, 66(1), 1996, pp. 24-35

Abstract

Day-old chicks trained on a single trial passive avoidance learning task showed a significant increase, relative to untrained controls, in activity of the Ca2+/calmodulin-dependent protein kinase (CaMK) in theparticulate fraction from tissues from the intermediate medial hyperstriatum ventrale region of the forebrain. The increased kinase activity was observed within 10 min following training and persisted for at least 70 min posttraining. Amnesia for the task was induced by micromolar concentrations of the specific CAMK II antagonist, KN-62, administered into the neostriatal/hyperstriatal region of the forebrain. The effect of KN-62 was lateralized. In the right hemisphere, KN-62 induced amnesia only when injected within 2.5 min following training, with memory loss evident by 5 min posttraining. In contrast, in the left hemisphere amnesia was induced by KN-62 administered as late as 5 min posttraining, with onset of amnesia occurring after 10 min posttraining. The findings were interpreted within the context of a three-stage model of memory formation. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:07:19