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Titolo:
AGE AND STRESS HISTORY EFFECTS ON SPATIAL PERFORMANCE IN A SWIM TASK IN FISCHER-344 RATS
Autore:
MABRY TR; MCCARTY R; GOLD PE; FOSTER TC;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Neurobiology of learning and memory
fascicolo: 1, volume: 66, anno: 1996,
pagine: 1 - 10
SICI:
1074-7427(1996)66:1<1:AASHEO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORRIS WATER MAZE; SYMPATHETIC-ADRENAL MEDULLARY; PLASMA-CATECHOLAMINE RESPONSES; CHRONIC INTERMITTENT STRESS; LONG-TERM POTENTIATION; F344 RATS; MEMORY; HIPPOCAMPUS; DEFICITS; INFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Mabry et al., "AGE AND STRESS HISTORY EFFECTS ON SPATIAL PERFORMANCE IN A SWIM TASK IN FISCHER-344 RATS", Neurobiology of learning and memory, 66(1), 1996, pp. 1-10

Abstract

This study determined whether prior habituation to water immersion would ameliorate age-related deficits in learning and memory in a swim task. Aged (22 months) and young adult (3 months) rats were immersed inwater (30 degrees C) for 15 min on each of 28 consecutive days beforetraining in the swim task. Additional groups of age-matched animals served as handled controls. Training on a spatial discrimination version of the water task was conducted over 5 days with two trials per day (1-h intertrial interval). A probe trial was substituted for the last trial on the fifth day to assess the rats' use of spatial information. Three days later, rats received cue discrimination training to find avisible platform. In the spatial task, prior habituation to water immersion ameliorated deficits in acquisition within each day (i.e., at a1-h intertrial interval) but not across days (at 24 h). The results obtained with the 24-h interval confirm the rapid forgetting characteristic of aged rats in many tasks. The stress-habituation procedures reduced age-related deficits seen on the probe trial and on cue discrimination training. These findings indicate that several aspects of age-related impairments in the swim task, often attributed to primary age-related deficits in learning and memory processes per se, may instead besecondary to age-related differences in stress responses to water immersion. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:34:12