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Titolo:
MORPHOLOGICAL ANALYSES OF GALANINERGIC INPUTS TO THE RAT SPINAL PARASYMPATHETIC NUCLEUS
Autore:
OHMACHI T; NAKAMURA T; ZHANG FZ; TANI I; TAKAGI H;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU,1-4-54 ASAHI MACHI OSAKA545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT UROL OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,ULTRASTRUCT LAB OSAKA 545 JAPAN
Titolo Testata:
Experimental Brain Research
fascicolo: 3, volume: 109, anno: 1996,
pagine: 399 - 406
SICI:
0014-4819(1996)109:3<399:MAOGIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; GENE-RELATED PEPTIDE; PREGANGLIONIC NEURONS; SUBSTANCE-P; CORD; IMMUNOREACTIVITY; PEROXIDASE; REGIONS;
Keywords:
GALANIN; PARASYMPATHETIC PREGANGLIONIC NEURONS; INTERMEDIOLATERAL NUCLEUS; FLUOROGOLD TRACER; CONFOCAL LASER MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
T. Ohmachi et al., "MORPHOLOGICAL ANALYSES OF GALANINERGIC INPUTS TO THE RAT SPINAL PARASYMPATHETIC NUCLEUS", Experimental Brain Research, 109(3), 1996, pp. 399-406

Abstract

We examined the characteristic features of galanin (GAL)-containing nerve afferents in the intermediolateral nucleus (IML) of the rat lumbosacral spinal cord (L6, S1), i.e., spinal parasympathetic nucleus, by immunocytochemistry at both light and electron microscopic levels. Firstly, the types of synapses formed by GAL-immunoreactive (IR) axon terminals and their post- or presynaptic elements were examined in randomultrathin sections, A total of 109 synapses were examined. Axodendritic (71%) and axe-somatic (20%) synapses were always of the asymmetrical type. Axo-axonic synapses (9%) were occasionally found; GAL-IR axon terminals were either postsynaptic (3%) or presynaptic (6%) to non-IR axon terminals. By confocal laser microscopy, many GAL-IR axon terminals were seen close to cell bodies and proximal dendrites of the IML neurons that were retrogradely labeled with Fluoro-Gold injected into the pelvic ganglion, Some GAL-IR axon terminals were identified to be presynaptic to them under the electron microscope, by restaining for GALimmunoreactivity with the immunoperoxidase method. These findings suggest that the GAL afferents are involved in the parasympathetic motor regulation of pelvic organs via their central synaptic influences uponpreganglionic neurons. Finally, hemi-transection of the upper lumbar segments (L1-L3) or unilateral dorsal rhizotomy (L5-S2) did not significantly alter the immunoreactivity for GAL in the IML. These results suggest that GAL afferents do not originate from regions rostral to theIML nor from the dorsal root ganglion, but probably from GAL cells located at least within the lower lumbar segments and/or sacral spinal cord.

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Documento generato il 26/09/20 alle ore 05:43:54