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Titolo:
INFLUENCE OF PH CHANGES ON THE ACTIONS OF VERAPAMIL ON VASCULAR EXCITATION-CONTRACTION COUPLING
Autore:
ACHIKE FI; DAI S; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHYSIOL,5 SASSOON RD HONG KONG HONG KONG UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG
Titolo Testata:
Environmental toxicology and pharmacology
fascicolo: 3, volume: 1, anno: 1996,
pagine: 207 - 212
SICI:
1382-6689(1996)1:3<207:IOPCOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-RESPONSES; INTRACELLULAR PH; CALCIUM BLOCKERS; SMOOTH-MUSCLE; NIFEDIPINE; RATS;
Keywords:
PH; VERAPAMIL; RAT TAIL ARTERY; EXCITATION-CONTRACTION COUPLING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F.I. Achike et al., "INFLUENCE OF PH CHANGES ON THE ACTIONS OF VERAPAMIL ON VASCULAR EXCITATION-CONTRACTION COUPLING", Environmental toxicology and pharmacology, 1(3), 1996, pp. 207-212

Abstract

We have previously shown that pH changes alter the cardiovascular responses to verapamil in rat, in vivo and in isolated rat heart. The current study investigated the influence of pH changes on the actions of verapamil on potassium- or noradrenaline-stimulated contraction in rattail arteries. The proximal 2-2.5 cm of ventral tail artery was bathed in and perfused initially (20-25 min) with physiological salt solution (pH 7.4) which was later made calcium-free at pH 7.4 (control), pH 7.2 (acidosis) or pH 7.67 (alkalosis), After equilibration each arterywas exposed to verapamil following which the contractile responses toincreasing concentrations of calcium were recorded. The patterns of responses in noradrenaline- or potassium-stimulated arteries were different. In normal conditions, the vasodilator effect of verapamil was predominant in potassium-stimulated arteries but less in the noradrenaline-stimulated preparations. With pH changes the effect of verapamil was enhanced more in noradrenaline- than in potassium-stimulated arteries. It is postulated that pathology-induced changes in the character ofcalcium channels could alter the effect of calcium channel blockers.

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Documento generato il 02/10/20 alle ore 00:50:28