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Titolo:
ERBB2 AND CHROMOSOME-17 CENTROMERE STUDIES OF OVARIAN-CANCER BY FLUORESCENCE IN-SITU HYBRIDIZATION
Autore:
YOUNG SR; LIU WH; BROCK JA; SMITH ST;
Indirizzi:
UNIV S CAROLINA,SCH MED,DEPT OBSTET & GYNECOL COLUMBIA SC 29208
Titolo Testata:
Genes, chromosomes & cancer
fascicolo: 2, volume: 16, anno: 1996,
pagine: 130 - 137
SICI:
1045-2257(1996)16:2<130:EACCSO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; HER-2/NEU EXPRESSION; TUMOR-ANTIGEN; AMPLIFICATION; GENE; ONCOGENE; OVEREXPRESSION; LOCALIZATION; ASSOCIATION; C-ERBB-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.R. Young et al., "ERBB2 AND CHROMOSOME-17 CENTROMERE STUDIES OF OVARIAN-CANCER BY FLUORESCENCE IN-SITU HYBRIDIZATION", Genes, chromosomes & cancer, 16(2), 1996, pp. 130-137

Abstract

More than 26,000 new cases of ovarian cancer are identified each yearin the United States, with almost 75% of these malignancies in advanced stages at the time of diagnosis. Early-stage disease has a cure rate of up to 90%, but the long-term survival rate of patients with advanced disease is 5-20%. At this time, there are no biomarkers that are effective indicators of early ovarian cancer. Recently, immunohistochemical and Southern blot studies have suggested that overexpression/amplification of the oncogene ERBB2 (HER2/neu) is associated with aggressive ovarian malignancies; however, some studies have not supported thisconclusion. Because tumor cells are known to be highly heterogeneous,we used fluorescence in situ hybridization (FISH) to study individualovarian cancer cells for HER2/neu amplification and chromosome 17 centromere copy number. Simultaneous multicolor cohybridization of HER2/neu and chromosome 17 centromere alpha-satellite probes were carried out on 43 ovarian cancer samples. Ten of the forty-three samples showed moderate to high amplification of HER2/neu, with varying numbers of chromosome 17 centromeres present. In some cells the amplified HER2/neu was dispersed throughout the nucleus, whereas in other cells the amplified oncogenes were clustered together. Within a sample there was heterogeneity in oncogene and centromere copy number. In this small study,we were unable to identify a specific clinical correlation. However, FISH is a powerful method for the study of oncogene amplification in tumor samples. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:18:58