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Titolo:
DRUG-SENSITIVITY TESTING FOR CLINICAL-SAMPLES FROM ESOPHAGEAL CANCER USING ADHESIVE TUMOR-CELL CULTURE SYSTEM
Autore:
TERASHIMA M; HAYASHI K; FUKUSHIMA M; IDE H; IIZUKA T; KAKEGAWA T; ANDO N; TANAKA O; SHINODA M; ISONO K; ISHIDA K; IKEUCHI S; ENDO M; TAKIYAMA W; YANAGAWA T;
Indirizzi:
IWATE MED UNIV,DEPT SURG 1,JAPANESE ESOPHAGEAL ONCOL GRP,19-1 UCHIMARU MORIOKA IWATE 020 JAPAN TOKYO WOMENS MED COLL,DEPT SURG,SHINJUKU KU TOKYO 162 JAPAN AICHI CANC CTR,DEPT INTERNAL MED,CHIKUSA KU NAGOYA AICHI 464 JAPAN NATL OHJI HOSP,DEPT SURG,KITA KU TOKYO 115 JAPAN KURUME UNIV,DEPT SURG 1 KURUME FUKUOKA 830 JAPAN KEIO UNIV,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN NIIGATA UNIV,DEPT SURG 1 NIIGATA 951 JAPAN AICHI CANC CTR,DEPT THORAC SURG,CHIKUSA KU NAGOYA AICHI 464 JAPAN CHIBA UNIV,DEPT SURG 2,CHUO KU CHIBA 280 JAPAN TOKYO NATL HOSP 2,DEPT SURG,MEGURO KU TOKYO 152 JAPAN TOKYO MED & DENT UNIV,DEPT SURG 1,BUNKYO KU TOKYO 113 JAPAN NATL SHIKOKU CANC CTR,DEPT SURG MATSUYAMA EHIME 790 JAPAN SRL INC HACHIOJI TOKYO 192 JAPAN
Titolo Testata:
British Journal of Cancer
fascicolo: 1, volume: 74, anno: 1996,
pagine: 73 - 77
SICI:
0007-0920(1996)74:1<73:DTFCFE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO; CISPLATIN; MATRIX;
Keywords:
ESOPHAGEAL CANCER; CHEMOSENSITIVITY TESTING; PRECLINICAL STUDY; ADHESIVE TUMOR CELL CULTURE SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Terashima et al., "DRUG-SENSITIVITY TESTING FOR CLINICAL-SAMPLES FROM ESOPHAGEAL CANCER USING ADHESIVE TUMOR-CELL CULTURE SYSTEM", British Journal of Cancer, 74(1), 1996, pp. 73-77

Abstract

A total of 83 specimens of surgically resected tumours from 78 patients with oesophageal cancer were assayed for drug sensitivity using an adhesive tumour cell culture system (LifeTrac CSA assay). Seventy-one of 83 specimens had a sufficient number of cells to permit growth in culture and 57 of 71 (80%) were evaluable for drug response. Cells (3 x10(3) ml(-1) well(-1)) were cultured for 14 days and exposed to drugson days 3-8. Growing cells were confirmed as cancer cells by immunohistochemical staining. IC90 values against several anti-cancer drugs were determined and population distributions of IC90 for each drug served as the basis for judging sensitivity. The 10th percentiles of IC90 (mu g ml(-1)) for CDDP, 5-FU, DOX, CPM, MTX, VP-16, IFOS, VDS, BLM and CDDP + 5-FU were 0.3, 0.16, 0.005, 0.9, 0.006, 0.09, 0.8, 0.006, 0.04 and 0.15 + 0.09 respectively. The population distribution of IC90 against each drug showed a specific pattern that was very similar among histopathological gradings and stages of the disease. This system appeared to be a clinically applicable drug sensitivity test for human oesophageal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:09:29