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Titolo:
REGULATION, SUBSTRATES AND FUNCTIONS OF SRC
Autore:
BROWN MT; COOPER JA;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST SEATTLE WA 98104 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104
Titolo Testata:
Biochimica et biophysica acta, CR. Reviews on cancer
fascicolo: 2-3, volume: 1287, anno: 1996,
pagine: 121 - 149
SICI:
0304-419X(1996)1287:2-3<121:RSAFOS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; ROUS-SARCOMA VIRUS; CELL ANTIGEN RECEPTOR; CHICKEN-EMBRYO FIBROBLASTS; AMINO-TERMINAL DOMAIN; MIDDLE-T-ANTIGEN; AFFINITY PHOSPHOTYROSYL PEPTIDE; MEDIATED SIGNAL-TRANSDUCTION; GTPASE-ACTIVATING PROTEIN; GROWTH-FACTOR RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
393
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Brown e J.A. Cooper, "REGULATION, SUBSTRATES AND FUNCTIONS OF SRC", Biochimica et biophysica acta, CR. Reviews on cancer, 1287(2-3), 1996, pp. 121-149

Abstract

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an example, and referring toother Src family members where appropriate, this review describes thestructure of Src, the functions of the individual domains, the regulation of Src kinase activity in the cell, the selection of substrates, and the biological functions of Src. The review concentrates on developments in the last 6-7 years, and cites data resulting from the isolation and characterization of Src mutants, crystallographic studies of the structures of SH2, SH3 and tyrosine kinase domains, biochemical studies of Src kinase activity and binding properties, and the biology oftransgenic and knockout mouse strains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:18:29