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Titolo:
A COMPARISON OF PATHOPHYSIOLOGICAL CHANGES DURING HYPOBARIC AND NORMOBARIC HYPOXIA IN RATS
Autore:
SHEEDY W; THOMPSON JS; MORICE AH;
Indirizzi:
UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT MED & PHARMACOL,GLOSSOP RDSHEFFIELD S10 2JF S YORKSHIRE ENGLAND
Titolo Testata:
Respiration
fascicolo: 4, volume: 63, anno: 1996,
pagine: 217 - 222
SICI:
0025-7931(1996)63:4<217:ACOPCD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; PULMONARY-HYPERTENSION; HEART; INFUSION; DISEASE; GROWTH; PLASMA; LUNG;
Keywords:
HYPOBARIC HYPOXIA; NORMOBARIC HYPOXIA; CHRONIC HYPOXIA; ATRIAL NATRIURETIC; PULMONARY HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W. Sheedy et al., "A COMPARISON OF PATHOPHYSIOLOGICAL CHANGES DURING HYPOBARIC AND NORMOBARIC HYPOXIA IN RATS", Respiration, 63(4), 1996, pp. 217-222

Abstract

Littermate male Wistar specific pathogen-free rats were divided into three groups at 28 days of age. The pathophysiological effects seen inrats exposed to normobaric hypoxia (NB) at 10% O-2 were compared withthose seen in animals exposed to hypobaric hypoxia (HB) at 500 mbar, equivalent to an inspired O-2 concentration of 10%, and controls afterperiods of 5, 10 and 14 days. 5 days' exposure to a low oxygen environment resulted in less weight gain, the development of right ventricular hypertophy and double elastic laminae in the pulmonary arterioles and an increase in haematocrit and plasma levels of atrial natriuretic peptide (ANP) in both the HB and NB animals compared to controls. There was no significant difference in these values between the two hypoxic groups. After 10 days' exposure to a low oxygen environment, body weight, ventricular ratio, plasma ANP levels and double elastic laminae were higher than the levels seen after 5 days in both NB and HB groupsof rats. At day 14 only body weight and haematocrit were greater whencompared to day 10 values in NB and HB groups. In conclusion the stress of this hypobaric environment caused no additional changes in the pathophysiological variables studied, compared with the changes seen inNB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:29:24