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Titolo:
CCK-58 - A NOVEL REAGENT FOR STUDYING THE REGULATION OF CHOLECYSTOKININ BIOACTIVITY
Autore:
RAYBOULD HE; REEVE JR;
Indirizzi:
W LOS ANGELES VET AFFAIRS MED CTR,CURE DIGEST DIS RES CTR,DEPT MED,ROOM 115,BLDG 115 LOS ANGELES CA 90073 W LOS ANGELES VET AFFAIRS MED CTR,CURE DIGEST DIS RES CTR,DEPT PHYSIOL LOS ANGELES CA 90073
Titolo Testata:
Peptides
fascicolo: 8, volume: 17, anno: 1996,
pagine: 1307 - 1311
SICI:
0196-9781(1996)17:8<1307:C-ANRF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; MK-329; BLOOD; FORM; RATS;
Keywords:
CCK-58; CHORECYSTOKININ; PANCREAS; PANCREATIC SECRETION; GASTRIC MOTILITY; BIOACTIVITY; STRUCTURE-FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Raybould e J.R. Reeve, "CCK-58 - A NOVEL REAGENT FOR STUDYING THE REGULATION OF CHOLECYSTOKININ BIOACTIVITY", Peptides, 17(8), 1996, pp. 1307-1311

Abstract

CCK-58 has been shown to be the major circulating form of the hormonein the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokininbioactivity. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:27:41