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Titolo:
INHIBITION OF HISTAMINE SYNTHESIS BY GLYCYRRHETINIC ACID IN MAST-CELLS COCULTURED WITH SWISS 3T3 FIBROBLASTS
Autore:
LEE YM; HIROTA S; JIPPOKANEMOTO T; KIM HR; SHIN TY; YEOM Y; LEE KK; KITAMURA Y; NOMURA S; KIM HM;
Indirizzi:
WONKWANG UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL CHONJU 570749 SOUTH KOREA WONKWANG UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL CHONJU 570749 SOUTH KOREA WONKWANG UNIV,MED RESOURCES RES CTR CHONJU 570749 SOUTH KOREA WONKWANG UNIV,SCH DENT,DEPT PHARMACOL IKSAN SOUTH KOREA WOOSUK UNIV,DEPT PHARM CHONJU SOUTH KOREA KIST,KOREA RES INST BIOSCI & BIOTECHNOL,DEV BIOTECHNOL LAB TAEJON SOUTH KOREA OSAKA UNIV,SCH MED,DEPT PATHOL OSAKA 530 JAPAN
Titolo Testata:
International archives of allergy and immunology
fascicolo: 3, volume: 110, anno: 1996,
pagine: 272 - 277
SICI:
1018-2438(1996)110:3<272:IOHSBG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-ENHANCING ACTIVITY; CONNECTIVE-TISSUE-TYPE; PROTEIN KINASE-C; GLUCOCORTICOID RECEPTORS; HISTIDINE-DECARBOXYLASE; PURIFICATION; INVITRO; BINDING; DEFICIENT; HEPARIN;
Keywords:
GLYCYRRHETINIC ACID; HISTIDINE DECARBOXYLASE; STEM CELL FACTOR; PROTEIN KINASE C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y.M. Lee et al., "INHIBITION OF HISTAMINE SYNTHESIS BY GLYCYRRHETINIC ACID IN MAST-CELLS COCULTURED WITH SWISS 3T3 FIBROBLASTS", International archives of allergy and immunology, 110(3), 1996, pp. 272-277

Abstract

The effect of glycyrrhetinic acid (18-O-beta-glycyrrhetinic acid, GA)on histamine metabolism was investigated in cultured mast cells (CMCs) cocultured with Swiss 3T3 fibroblasts. GA strongly inhibited histamine synthesis in the cocultured CMCs. Since 50 mu M GA inhibited about 80% of histidine decarboxylase (HDC) activity, the inhibitory activityof GA for histamine synthesis was considered to be derived from the inhibition of HDC activity. The number of berberine-sulfate-positive cells also decreased in the presence of GA, which indicated that maturation of CMCs was inhibited by GA. Furthermore, we examined the effect of GA on the mRNA expression of novel protein kinase C delta (nPKC delta), a major isoform of CMCs, by Northern blot analysis. The expressionof nPKC delta mRNA in the presence of GA was significantly lower thanin the absence of GA. These results suggest the possibility that the inhibition of histamine synthesis by GA is regulated by nPKC delta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:29:44