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Titolo:
SUSCEPTIBILITY TO MACROLIDE AND BETA-LACTAM ANTIBIOTICS OF STREPTOCOCCUS-PYOGENES STRAINS ISOLATED OVER A 4-YEAR PERIOD IN CENTRAL ITALY
Autore:
CELLESI C; CHIGIOTTI S; ZANCHI A; MENCARELLI M; CORBISIERO R; ROSSOLINI GM;
Indirizzi:
UNIV SIENA,IST MALATTIE INFETT,VIA PA MATTIOLI 10 I-53100 SIENA ITALY UNIV SIENA,INST INFECT DIS I-53100 SIENA ITALY
Titolo Testata:
Journal of chemotherapy
fascicolo: 3, volume: 8, anno: 1996,
pagine: 188 - 192
SICI:
1120-009X(1996)8:3<188:STMABA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-A STREPTOCOCCI; PHARMACOKINETIC PROPERTIES; HEMOLYTIC STREPTOCOCCI; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; CLINICAL EFFICACY; INVASIVE GROUP; ERYTHROMYCIN; INFECTIONS; AZITHROMYCIN;
Keywords:
STREPTOCOCCUS PYOGENES; MACROLIDES; BETA-LACTAMS; CEFTIBUTEN; CEFTRIAXONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Cellesi et al., "SUSCEPTIBILITY TO MACROLIDE AND BETA-LACTAM ANTIBIOTICS OF STREPTOCOCCUS-PYOGENES STRAINS ISOLATED OVER A 4-YEAR PERIOD IN CENTRAL ITALY", Journal of chemotherapy, 8(3), 1996, pp. 188-192

Abstract

In vitro susceptibility to erythromycin, azithromycin, penicillin G, ceftriaxone and ceftibuten was investigated in 190 Streptococcus pyogenes strains isolated over a 4-year period (1998-1994) from patients attending a university hospital located in central Italy. The rate of susceptibility to macrolide antibiotics of the S. pyogenes strains showed a progressive decrease (from 90.3% in 1991 to 79.5% in 1994), while all strains were susceptible to the three beta-lactam antibiotics. Owing to the reduced prevalence of macrolide-susceptible S. pyogenes strains, in vitro susceptibility testing of streptococcal isolates appearsto be always necessary before starting a macrolide-based chemotherapy. Concerning beta-lactams, ceftriaxone presented minimum inhibitory concentrations (MIG) always equal to or lower than those of penicillin G, while the oral long-acting cephalosporin, ceftibuten, had MICs higher than those of the other beta-lactams, although in the susceptible range. Results of in vitro susceptibility testing are discussed in relation to their implications for antimicrobial chemotherapy of S. pyogenes infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 08:00:50