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Titolo:
POLYMORPHIC AMINO-ACID DOMAINS OF THE HLA-DQ MOLECULE ARE ASSOCIATED WITH DISEASE HETEROGENEITY IN MYASTHENIA-GRAVIS
Autore:
HJELMSTROM P; GISCOMBE R; LEFVERT AK; PIRSKANEN R; KOCKUM I; LANDINOLSSON M; SANJEEVI CB;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MED S-10401 STOCKHOLM SWEDEN KAROLINSKA INST,SODER HOSP,DEPT NEUROL STOCKHOLM SWEDEN LUND UNIV,DEPT MED LUND SWEDEN
Titolo Testata:
Journal of neuroimmunology
fascicolo: 2, volume: 65, anno: 1996,
pagine: 125 - 131
SICI:
0165-5728(1996)65:2<125:PADOTH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; SUSCEPTIBILITY; RESISTANCE; ANTIGEN;
Keywords:
MYASTHENIA GRAVIS; HLA-DQ; DISEASE HETEROGENEITY; PCR-SSO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Hjelmstrom et al., "POLYMORPHIC AMINO-ACID DOMAINS OF THE HLA-DQ MOLECULE ARE ASSOCIATED WITH DISEASE HETEROGENEITY IN MYASTHENIA-GRAVIS", Journal of neuroimmunology, 65(2), 1996, pp. 125-131

Abstract

The association between myasthenia gravis (MG) and polymorphic amino acid domains in the HLA-DQ molecule was studied in 79 Swedish patientsand 155 unrelated, population-based controls. A domain unique for DQB10201 was positively associated in MG patients with thymic hyperplasia or an early disease onset, and two domains with residues common to DQA101 alleles or DQB1*05 and DQB1*06 alleles were negatively associated in patients with thymic hyperplasia or an early disease onset. Our results suggest that MG associated with thymic hyperplasia and thymomadiffer in their HLA-DQ association and thus are likely to have different pathogenic mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:05:56