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Titolo:
ANTIDEPRESSANT DRUGS GIVEN REPEATEDLY CHANGE THE BINDING OF THE DOPAMINE D-2 RECEPTOR AGONIST, [H-3] N-0437, TO DOPAMINE D-2 RECEPTORS IN THE RAT-BRAIN
Autore:
MAJ J; DZIEDZICKAWASYLEWSKA M; ROGOZ R; ROGOZ Z; SKUZA G;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,12 SMETNA ST PL-31343 KRAKOW POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1-3, volume: 304, anno: 1996,
pagine: 49 - 54
SICI:
0014-2999(1996)304:1-3<49:ADGRCT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-DEPRESSANT TREATMENT; NUCLEUS ACCUMBENS; LOCOMOTOR RESPONSE; SUPER-SENSITIVITY; INVITRO BINDING; D-AMPHETAMINE; SYSTEM; DESIPRAMINE; IMIPRAMINE; ALPHA-1-ADRENOCEPTORS;
Keywords:
ANTIDEPRESSANT; REPEATED TREATMENT; DOPAMINE D-2 RECEPTOR BINDING; [H-3] N-0437;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J. Maj et al., "ANTIDEPRESSANT DRUGS GIVEN REPEATEDLY CHANGE THE BINDING OF THE DOPAMINE D-2 RECEPTOR AGONIST, [H-3] N-0437, TO DOPAMINE D-2 RECEPTORS IN THE RAT-BRAIN", European journal of pharmacology, 304(1-3), 1996, pp. 49-54

Abstract

The effects of antidepressants given in a single dose or repeatedly (10 mg/kg p.o., twice daily, 14 days) on binding to dopamine D-2 receptors in the striatum and limbic forebrain of Wistar male rats were studied. [H-3]N-0437, propyl-N-(2-triofuranyl)-2'-ethylamino)-5-hydroxy- 1,2,3,4-tetrahydronaphthalene), a dopamine D-2 receptor agonist, was used as a ligand. Already a single dose of imipramine and fluoxetine caused a statistically significant decrease in the affinity of the ligandfor dopamine D-2 receptors in the striatum, but only at 72 h after drug administration. Also at 72 h after the single dose of mianserin a significant increase in the density of dopamine D-2 receptors was observed. Repeated imipramine, amitriptyline and mianserin increased the affinity for dopamine D-2 receptors in the striatum and in the limbic forebrain. Repeated fluoxetine increased that affinity in the striatum, but decreased it in the limbic forebrain. The density of dopamine D-2 receptors was increased by the repeated administration of the antidepressants studied in the limbic forebrain, but was not changed in the striatum. The results obtained in the present study are in good agreement with the previously reported enhancement of behavioural responsiveness to dopamine and dopamine stimulants (dopamine D-2 up-regulation) evoked by repeated treatment with antidepressants.

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Documento generato il 25/01/20 alle ore 09:27:25