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Titolo:
DECREASED HEDONIC RESPONSIVENESS FOLLOWING CHRONIC MILD STRESS IS NOTSECONDARY TO LOSS OF BODY-WEIGHT
Autore:
WILLNER P; MOREAU JL; NIELSEN CK; PAPP M; SLUZEWSKA A;
Indirizzi:
UNIV COLL SWANSEA,DEPT PSYCHOL SWANSEA SA2 8PP W GLAM WALES F HOFFMANN LA ROCHE & CO LTD CH-4002 BASEL SWITZERLAND H LUNDBECK & CO AS DK-2500 COPENHAGEN DENMARK POLISH ACAD SCI,INST PHARMACOL PL-31343 KRAKOW POLAND MED ACAD POZNAN,DEPT PHARMACOL PL-61701 POZNAN POLAND
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 60, anno: 1996,
pagine: 129 - 134
SICI:
0031-9384(1996)60:1<129:DHRFCM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ANHEDONIA; ANIMAL-MODEL; AFFECTIVE-DISORDER; ANOREXIA-NERVOSA; DEPRESSION; PREFERENCE; ANTIDEPRESSANT; ATTENUATION; REDUCTION; DOPAMINE;
Keywords:
CHRONIC MILD STRESS; ANHEDONIA; SUCROSE CONSUMPTION; SACCHARIN CONSUMPTION; BRAIN STIMULATION REWARD; BODY WEIGHT; RATS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Willner et al., "DECREASED HEDONIC RESPONSIVENESS FOLLOWING CHRONIC MILD STRESS IS NOTSECONDARY TO LOSS OF BODY-WEIGHT", Physiology & behavior, 60(1), 1996, pp. 129-134

Abstract

Chronic exposure to mild unpredictable stress (CMS) has previously been found to decrease hedonic responsiveness, as measured by the consumption of palatable sweet solutions or sensitivity to brain stimulationreward. These effects are reversed by chronic treatment with antidepressant drugs, and the CMS procedure has been proposed as a relatively valid animal model of depression. It has recently been suggested that the behavioural effects of CMS may be secondary to loss of body weight. This article collates data from five laboratories using the CMS procedure. Data are presented from seven studies using five different rat strains, as well as CD1 mice. Three-week exposure to CMS significantlydecreased sucrose consumption by Lister hooded, PVG hooded, Wistar, and Wistar WU rats, and by CD1 mice, and sensitivity to brain stimulation reward in Ibm:Ro Ro rats. Weight loss in different experiments varied between 0 and 10%. Hedonic sensitivity relative to body weight (e.g., mg sucrose/g body weight) decreased significantly in all experiments. Animals maintained on a restricted feeding regime lost weight but did not show decreases in sucrose intake. It is concluded that decreased hedonic sensitivity following chronic mild stress cannot be attributed to loss of body weight.

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Documento generato il 22/01/20 alle ore 18:31:53