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Titolo:
EFFECT OF PG-SPI AND PG-KII, 2 NOVEL AND NATURAL TACHYKININS, ON SALIVARY SECRETION IN THE RAT
Autore:
BROCCARDO M; IMPROTA G; BRANDONI A; TABACCO A;
Indirizzi:
UNIV ROMA LA SAPIENZA,INST PHARMACOL,PIAZZALE ALDO MORO 5 I-00185 ROME ITALY
Titolo Testata:
Peptides
fascicolo: 4, volume: 17, anno: 1996,
pagine: 729 - 731
SICI:
0196-9781(1996)17:4<729:EOPAP2>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE AGONISTS; RECEPTORS;
Keywords:
TACHYKININS; PG-SPI; PG-KII; SALIVARY SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Broccardo et al., "EFFECT OF PG-SPI AND PG-KII, 2 NOVEL AND NATURAL TACHYKININS, ON SALIVARY SECRETION IN THE RAT", Peptides, 17(4), 1996, pp. 729-731

Abstract

In an in vivo study of salivation in rats, the scialogogic effects oftwo natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank orderof potencies of these peptides injected intravenously on salivation was: PG-SPI = SP greater than or equal to PG-KII = KASS > NKA >> NKB. Atropine (1 mg/kg, IV) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We concludethat PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI- and PG-KII-sensitive receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:01:02