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Titolo:
HIGH-SENSITIVITY COLLISIONALLY-ACTIVATED DECOMPOSITION TANDEM MASS-SPECTROMETRY ON A NOVEL QUADRUPOLE ORTHOGONAL-ACCELERATION TIME-OF-FLIGHT MASS-SPECTROMETER/
Autore:
MORRIS HR; PAXTON T; DELL A; LANGHORNE J; BERG M; BORDOLI RS; HOYES J; BATEMAN RH;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM LONDON SW7 2AZ ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOL LONDON SW7 2AZ ENGLAND MIRCOMASS LTD MANCHESTER M23 9LZ LANCS ENGLAND
Titolo Testata:
Rapid communications in mass spectrometry
fascicolo: 8, volume: 10, anno: 1996,
pagine: 889 - 896
SICI:
0951-4198(1996)10:8<889:HCDTM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Morris et al., "HIGH-SENSITIVITY COLLISIONALLY-ACTIVATED DECOMPOSITION TANDEM MASS-SPECTROMETRY ON A NOVEL QUADRUPOLE ORTHOGONAL-ACCELERATION TIME-OF-FLIGHT MASS-SPECTROMETER/", Rapid communications in mass spectrometry, 10(8), 1996, pp. 889-896

Abstract

Consideration of the special problems encountered in ultra-high sensitivity biopolymer sequencing studies has led to the development of a novel quadrupole/orthogonal-acceleration time-of-flight tandem mass spectrometer described for the first time here, The performance characteristics of this new geometry are demonstrated, including fully resolveddaughter-ion spectra with mass accuracies of 0.1 dalton, which allow removal of interpretation ambiguities and easy differentiation of charge states even in weak collisionally-activated decomposition tandem mass spectra, The instrument has been applied to a variety of biopolymerresearch problems, including the structure determination of major histocompatibility complex peptide antigens using liquid chromatography/electrospray mass spectrometry and nanoflow-electrospray tandem mass spectrometry, and sequencing capability in the low-femtomole and attomole ranges is demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:27:40