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Titolo:
PLATELET ADENYLYL-CYCLASE ACTIVITY IN ALCOHOLICS AND SUBTYPES OF ALCOHOLICS
Autore:
PARSIAN A; TODD RD; CLONINGER CR; HOFFMAN PL; OVCHINNIKOVA L; IKEDA H; TABAKOFF B; SCHUCKIT MA; RAPPAPORT M; TSUANG J; SALASPURO M; MONTEIRO MG; BALANT LP; DAVIDSON C; OGATA M; YAMASHITA I; GRANT BF;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 UNIV COLORADO,SCH MED,DEPT PHARMACOL DENVER CO 80262
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 4, volume: 20, anno: 1996,
pagine: 745 - 751
SICI:
0145-6008(1996)20:4<745:PAAIAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
G-PROTEINS; IDENTIFICATION; HETEROGENEITY; LYMPHOCYTES; DEPENDENCE; ENZYME; LOCUS;
Keywords:
ADENYLYL CYCLASE; ALCOHOLIC SUBTYPES; FLUORIDE STIMULATION; G(S)ALPHA/G(I)ALPHA PROTEINS; LINEAR REGRESSION ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Parsian et al., "PLATELET ADENYLYL-CYCLASE ACTIVITY IN ALCOHOLICS AND SUBTYPES OF ALCOHOLICS", Alcoholism, clinical and experimental research, 20(4), 1996, pp. 745-751

Abstract

Adenylyl cyclase (AC) activity was measured in membrane preparations of platelets from control and alcoholic subjects. The sample consistedof 51 alcoholics who were categorized as type I or type II using the criteria of Gilligan et al. (Genet. Epidemiol. 4:395-414, 1987) and 54normal controls. Alcoholic males exhibited significantly lower valuesthan controls in basal and fluoride-stimulated platelet AC activity. When male alcoholics were segregated into type I and type II categories, the platelet AC activity did not differ between subtypes, and both subtypes had AC activity that was below control values. Western blot analysis of the quantity of G(s) alpha and G(i) alpha proteins in a subset of male controls and alcoholic subjects demonstrated no significant relationship between quantity of G proteins and AC activity. The results confirm lower platelet AC activity in male alcoholics, compared with controls. Given the lack of quantitative relations between G(s) alpha and G(i) alpha proteins and AC activity, the results support the contention that individual differences in platelet AC activity in the alcoholic subjects may reflect quantitative or qualitative differences in the AC catalytic units.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:13:10