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Titolo:
CLONING AND SEQUENCING A HUMAN HOMOLOG (HMYH) OF THE ESCHERICHIA-COLIMUTY GENE WHOSE FUNCTION IS REQUIRED FOR THE REPAIR OF OXIDATIVE DNA-DAMAGE
Autore:
SLUPSKA MM; BAIKALOV C; LUTHER WM; CHIANG JH; WEI YF; MILLER JH;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,INST MOLEC BIOL LOS ANGELES CA 90024 HUMAN GENOME SCI ROCKVILLE MD 20850
Titolo Testata:
Journal of bacteriology
fascicolo: 13, volume: 178, anno: 1996,
pagine: 3885 - 3892
SICI:
0021-9193(1996)178:13<3885:CASAHH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTAGENIC SUBSTRATE; HYDROLYZES; EXPRESSION; MUTATIONS; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Slupska et al., "CLONING AND SEQUENCING A HUMAN HOMOLOG (HMYH) OF THE ESCHERICHIA-COLIMUTY GENE WHOSE FUNCTION IS REQUIRED FOR THE REPAIR OF OXIDATIVE DNA-DAMAGE", Journal of bacteriology, 178(13), 1996, pp. 3885-3892

Abstract

We have cloned the human mutY gene (hMYH) from both genomic and cDNA libraries. The human gene contains 15 introns and is 7.1 kb long. The 16 exons encode a protein of 535 amino acids that displays 41% identity to the Escherichia coli protein, which provides an important function in the repair of oxidative damage to DNA and helps to prevent mutations from oxidative lesions. The human mutY gene maps on the short arm of chromosome 1, between p32.1 and p34.3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:18:24