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Titolo:
THE GROWTH HORMONE-RELEASING PEPTIDE KP-102 INDUCES C-FOS EXPRESSION IN THE ARCUATE NUCLEUS
Autore:
KAMEGAI J; HASEGAWA O; MINAMI S; SUGIHARA H; WAKABAYASHI I;
Indirizzi:
NIPPON MED COLL,DEPT MED,BUNKYO KU,SENDAGI 1-1-5 TOKYO 113 JAPAN
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 39, anno: 1996,
pagine: 153 - 159
SICI:
0169-328X(1996)39:1-2<153:TGHPKI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL MEN; SYNTHETIC HEXAPEPTIDE; HYPOTHALAMIC ARCUATE; INVIVO ACTIVITY; FACTOR NEURONS; GH SECRETION; RAT; SOMATOSTATIN; PITUITARY; HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2;
Keywords:
C-FOS; GROWTH HORMONE-RELEASING PEPTIDE; GROWTH HORMONE; GROWTH HORMONE-RELEASING FACTOR; SOMATOSTATIN; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Kamegai et al., "THE GROWTH HORMONE-RELEASING PEPTIDE KP-102 INDUCES C-FOS EXPRESSION IN THE ARCUATE NUCLEUS", Molecular brain research, 39(1-2), 1996, pp. 153-159

Abstract

Growth hormone-releasing hexapeptide (GHRP) stimulates GH secretion by acting on both the pituitary and the hypothalamus through a poorly understood mechanism. To reveal the hypothalamic action of GHRP, rat brains were processed for in situ hybridization for c-fos mRNA as a marker of neuronal activity after systemic administration of a newly developed GHRP, KP-102. Hypophysectomized adult male Wistar rats were administered KP-102 through an indwelling right atrial cannula. KP-102 treatment was accompanied by transient expression of the c-fos gene selectively in the ventromedial and ventrolateral regions of the arcuate nucleus (ARC). The distribution of c-fos gene-expressing cells overlappedthat of GRF mRNA-containing neurons in the ventrolateral region on adjacent sections, whereas few c-fos mRNA signals were detected in the dorsomedial region where somatostatin mRNA signals were localized. To confirm this observations, hypothalamic sections were subjected to double-label in situ hybridization. Twenty-three percent of c-Sos mRNA-containing cells were GRF neurons, comprising 20% of the GRF neurons in the ARC. The remaining c-fos mRNA containing cells were unidentified. KP-102 thus appears to act on a subpopulation of GRF neurons and unidentified cells in the ARC to stimulate GH secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:24:34