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Titolo:
MR-BASED CORRECTION OF BRAIN PET MEASUREMENTS FOR HETEROGENEOUS GRAY-MATTER RADIOACTIVITY DISTRIBUTION
Autore:
MELTZER CC; ZUBIETA JK; LINKS JM; BRAKEMAN P; STUMPF MJ; FROST JJ;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,600 N WOLFE ST,B1-130 NELSON TOWER BLDG BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NUCL MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NEURORADIOL BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT ENVIRONM HLTH SCI BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT NEUROSCI BALTIMORE MD 21205
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 4, volume: 16, anno: 1996,
pagine: 650 - 658
SICI:
0271-678X(1996)16:4<650:MCOBPM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBROSPINAL-FLUID VOLUMES; COMPUTED-TOMOGRAPHY; MAGNETIC-RESONANCE; CEREBRAL ATROPHY; ALZHEIMERS-DISEASE; WHITE-MATTER; DEMENTIA; IMAGES; CT;
Keywords:
ALZHEIMER DISEASE; EMISSION COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING; OPIATE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Meltzer et al., "MR-BASED CORRECTION OF BRAIN PET MEASUREMENTS FOR HETEROGENEOUS GRAY-MATTER RADIOACTIVITY DISTRIBUTION", Journal of cerebral blood flow and metabolism, 16(4), 1996, pp. 650-658

Abstract

Partial volume and mixed tissue sampling errors can cause significantinaccuracy in quantitative positron emission tomographic (PET) measurements. We previously described a method of correcting PET data for the effects of partial volume averaging on gray matter (GM) quantitation; however, this method may incompletely correct GM structures when local tissue concentrations are highly heterogeneous. We have extended this three-compartment algorithm to include a fourth compartment: a GM volume of interest (VOI) that can be delineated on magnetic resonance (MR) imaging, Computer simulations of PET images created from human MR data demonstrated errors of up to 120% in assigned activity values in small brain structures in uncorrected data. Four-compartment correction achieved full recovery of a wide range of coded activity in GM VOIs such as the amygdala, caudate, and thalamus. Further validation was performed in an agarose brain phantom in actual PET acquisitions. Implementation of this partial volume correction approach in [F-18]fluorodeoxyglucose and [C-11]carfentanil PET data acquired in a healthy elderlyhuman subject was also performed. This newly developed MR-based partial volume correction algorithm permits the accurate determination of the true radioactivity concentration in specific structures that can bedefined by MR by accounting for the influence of heterogeneity of GM radioactivity.

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Documento generato il 03/07/20 alle ore 22:08:32