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Titolo:
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN SERA FROM COLECTOMISED ULCERATIVE-COLITIS PATIENTS AND ITS RELATION TO THE PRESENCE OF POUCHITIS
Autore:
ESTEVE M; MALLOLAS J; KLAASSEN J; ABADLACRUZ A; GONZALEZHUIX F; CABRE E; FERNANDEZBANARES F; BERTRAN X; CONDOM E; MARTIRAGUE J; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS I PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET S-N E-08916 BARCELONA SPAIN HOSP UNIV GERMANS TRIAS I PUJOL,DEPT GASTROENTEROL E-08916 BARCELONA SPAIN HOSP SANT LLORENC,DEPT GASTROENTEROL VILADECANS SPAIN HOSP JOSEP TRUETA,DEPT GASTROENTEROL GIRONA SPAIN CIUTAT SANITARIA UNIV BELLVITGE,DEPT SURG LHOSPITALET LLOBR SPAIN CIUTAT SANITARIA UNIV BELLVITGE,DEPT PATHOL LHOSPITALET LLOBR SPAIN
Titolo Testata:
Gut
fascicolo: 6, volume: 38, anno: 1996,
pagine: 894 - 898
SICI:
0017-5749(1996)38:6<894:ACAISF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ANCA;
Keywords:
ULCERATIVE COLITIS; PROCTOCOLECTOMY; ILEAL POUCH ANAL ANASTOMOSIS; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; POUCHITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Esteve et al., "ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN SERA FROM COLECTOMISED ULCERATIVE-COLITIS PATIENTS AND ITS RELATION TO THE PRESENCE OF POUCHITIS", Gut, 38(6), 1996, pp. 894-898

Abstract

Background-Few studies have evaluated the influence of colectomy on antineutrophil cytoplasmic antibody (ANCA) positivity in ulcerative colitis (UC). In small series of patients it has been suggested that ANCApositivity in UC might be predictive for development of pouchitis after colectomy. Aims-To assess the prevalence of ANCA in UC patients treated by colectomy and a Brooke's ileostomy (UC-BI) or ileal pouch analanastomosis (UC-IPAA), and the relation between the presence of ANCA,the type of surgery, and the presence of pouchitis. Subjects-63 UC patients treated by colectomy (32 with UC-BI and 31 with UC-IPAA), 54 UC, and 24 controls. Methods-Samples were obtained at least two years after colectomy. ANCA were detected by indirect immunofluorescent assay. Results-There were no differences between patients with (36.3%) or without pouchitis (35.0%) and between patients with UC (55%), UC-BI (40.6%), and UC-IPAA (35.4%). However, ANCA prevalence significantly decreases in the whole group of operated patients (38.0%) compared with non-operated UC (p=0.044). Conclusions-The prevalence of ANCA in operatedpatients was significantly lower than in non-operated UC, suggesting that it might be related either to the presence of inflamed or diseased tissue. ANCA persistence is not related to the surgical procedure and it should not be used as a marker for predicting the development of pouchitis.

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Documento generato il 29/11/20 alle ore 10:08:06