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Titolo:
DYSREGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL SYSTEM IN PANIC DISORDER
Autore:
SCHREIBER W; LAUER CJ; KRUMREY K; HOLSBOER F; KRIEG JC;
Indirizzi:
UNIV MARBURG,DEPT PSYCHIAT,RUDOLF BULTMANN STR 8 D-35033 MARBURG GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT PSYCHIAT W-8000 MUNICH GERMANY
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 15, anno: 1996,
pagine: 7 - 15
SICI:
0893-133X(1996)15:1<7:DOTHSI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; URINARY FREE CORTISOL; ANXIETY DISORDERS; LOCUS-CERULEUS; RAT-BRAIN; MATERNAL SEPARATION; NEURO-ENDOCRINE; STRESS; HORMONE; DEXAMETHASONE;
Keywords:
PANIC DISORDER; MAJOR DEPRESSION; DEXAMETHASONE-CORTICOTROPIN-RELEASING HORMONE (DEX-CRH) CHALLENGE TEST; ACTH; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
W. Schreiber et al., "DYSREGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL SYSTEM IN PANIC DISORDER", Neuropsychopharmacology, 15(1), 1996, pp. 7-15

Abstract

The responsiveness of the hypothalamic-pituitary-adrenocortical (HPA)system (HPA) investigated with the combined dexamethasone-corticotropin-releasing hormone (DEX-CRH) challenge test in 13 patients with ''pure'' panic disorder After DEX pretreatment, this group of patients hadhigher CRH-induced adrenocorticotrophic hormone (ACTH) and cortisol levels than the control group, but lower levels than a reference group of depressed patients. The panic disorder patients were also in a middle position in the ratio of suppressors to nonsuppressors on the dexamethasone suppression test (DST) and in the ratio of normal to abnormalresults on the DEX-CRH test. Our results using the combined DEX-CRH test, which is known to be much more sensitive than the original DST, support the hypothesis that HPA system functioning is altered in panic disorder patients and that this dysregulation is directly involved in the pathogenesis of the disorder.

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Documento generato il 27/01/20 alle ore 13:55:16